Enlibio，Your biological research partner ！
 Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large gr AbstractT cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common. Althoug... |
 Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mech AbstractWhole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and the associated toxicity have q... |
 A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and pers AbstractPolygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-... |
 AbstractMucosal linings of the body, including the conjunctiva, are enriched in tissue-resident memory T cells (TRMs) whose defining feature is their continual tissue protection that does not rely ... |
 A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyt AbstractHuman leukocyte antigen loss of heterozygosity (HLA LOH) allows cancer cells to escape immune recognition by deleting HLA alleles, causing the suppressed presentation of tumor neoantigens. ... |
 The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the C AbstractComplement activation on cell surfaces leads to the massive deposition of C3b, iC3b, and C3dg, the main complement opsonins. Recognition of iC3b by complement receptor type 3 (CR3) fosters ... |
 Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhib AbstractImmune checkpoint inhibitors are associated with immune-related adverse events (irAEs), including arthritis (arthritis-irAE). Management of arthritis-irAE is challenging because immunomodul... |
 AbstractCancer cells within a tumour have heterogeneous phenotypes and exhibit dynamic plasticity. How to evaluate such heterogeneity and its impact on outcome and drug response is still unclear. H... |
 AbstractThere is evidence that tumor immunobiology and immunotherapy response may differ between African American and European American prostate cancer patients. Here, we determine if men of Africa... |
 PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell a AbstractMyeloid cells play key roles in cancer immune suppression and tumor progression. In response to tumor derived factors, circulating monocytes and granulocytes extravasate into the tumor pare... |
|
|
