Immunology
Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessme
Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessme
Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessmentAbstractThe immune imprinting against SARS-CoV-2 subvariants that dynamically evolves through s...
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction w
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction w
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptorsAbstractAmyloid proteins are linked to various diseases; however, their f...
Heme processing in the malaria parasite, Plasmodium falciparum: a time-dependent basal-level analysi
Heme processing in the malaria parasite, Plasmodium falciparum: a time-dependent basal-level analysi
Heme processing in the malaria parasite, Plasmodium falciparum: a time-dependent basal-level analysisAbstractMalaria is a deadly disease for which therapeutic options are threatened by the rise of ...
qMaLioffG: a genetically encoded green fluorescence lifetime-based indicator enabling quantitative i
qMaLioffG: a genetically encoded green fluorescence lifetime-based indicator enabling quantitative i
qMaLioffG: a genetically encoded green fluorescence lifetime-based indicator enabling quantitative imaging of intracellular ATPAbstractGenetically encoded indicators that can detect concentrations ...
Irradiated obese adipocytes are prone to oxidative stress, inflammation, senescence, and fibrosis
Irradiated obese adipocytes are prone to oxidative stress, inflammation, senescence, and fibrosis
Irradiated obese adipocytes are prone to oxidative stress, inflammation, senescence, and fibrosisAbstractCancer patients with obesity who undergo radiotherapy are more likely to suffer from side ef...
Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneo
Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneo
Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneous insulin receptor endocytosisAbstractDysregulation of heat shock protein DNAJA2 induces genomic...
Near telomere to telomere genome assembly of Chinese yellow rabbit (Oryctolagus cuniculus)
Near telomere to telomere genome assembly of Chinese yellow rabbit (Oryctolagus cuniculus)
Near telomere to telomere genome assembly of Chinese yellow rabbit (Oryctolagus cuniculus)AbstractOryctolagus cuniculus (Fujian Yellow Rabbit; FJY), the only indigenous rabbit breed in China, known...
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1AbstractTumor necrosis factor (TNF)-induced RIPK1-mediated cell death is implicated in various huma...
Mixed granulocytic airway inflammation impairs aversive learning and alters neuroimmune biomarkers i
Mixed granulocytic airway inflammation impairs aversive learning and alters neuroimmune biomarkers i
Mixed granulocytic airway inflammation impairs aversive learning and alters neuroimmune biomarkers in miceAbstractAsthma is characterized by different phenotypes of airway inflammation, granulocyti...
Comparison of basophil activation testing and component-resolved diagnosis in patients with cross-re
Comparison of basophil activation testing and component-resolved diagnosis in patients with cross-re
Comparison of basophil activation testing and component-resolved diagnosis in patients with cross-reactive intradermal results after anaphylactic reactions to hymenoptera venomAbstractHymenoptera v...
Dual effects of the alternative spliced RIG-I isoform PTIR1 on host antiviral defense and immune hom
Dual effects of the alternative spliced RIG-I isoform PTIR1 on host antiviral defense and immune hom
Dual effects of the alternative spliced RIG-I isoform PTIR1 on host antiviral defense and immune homeostasisAbstractEfficient pathogen recognition must be tightly regulated to prevent immunopatholo...
Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervent
Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervent
Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic interventionAbstractHuman T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) is a debilitat...
LUBAC modulates CBM complex functions downstream of TRAF6 in T cells
LUBAC modulates CBM complex functions downstream of TRAF6 in T cells
LUBAC modulates CBM complex functions downstream of TRAF6 in T cellsAbstractThe CARD11-BCL10-MALT1 (CBM) complex drives NF-κB signaling and MALT1 protease activation after T cell receptor (TCR) sti...
Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsis
Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsis
Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsisAbstractSepsis-induced liver injury is common, but the underlying mechanisms remain poorly understood. Given t...
CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional dow
CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional dow
CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagyAbstractVascular smooth muscle cells (VSMCs) are a significant source of ...
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome indu
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome indu
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegansAbstractTranscription factors DAF-16/FOXO and HLH-30/TFEB have been linked to ...
HMGB1 mediated autophagy and apoptosis in human nucleus pulposus cells; chloroquine amplified apopto
HMGB1 mediated autophagy and apoptosis in human nucleus pulposus cells; chloroquine amplified apopto
HMGB1 mediated autophagy and apoptosis in human nucleus pulposus cells; chloroquine amplified apoptosis by inhibiting autophagyAbstractInvestigate the cellular response of human nucleus pulposus (H...
Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cance
Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cance
Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cancerAbstractCurcumin has attracted attention for its nontoxic chemopreventive effects; however, the ...
Identification and localization of telocyte-like cells in human umbilical cord stroma
Identification and localization of telocyte-like cells in human umbilical cord stroma
Identification and localization of telocyte-like cells in human umbilical cord stromaAbstractHuman umbilical cord (hUC) connective tissue, known as Wharton’s jelly, contains multipotent stromal cel...
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
The methyl-CpG-binding protein 2 inhibits cGAS-associated signalingAbstractThe detection of cytosolic dsDNA by the cyclic GMP-AMP synthase (cGAS) is tightly regulated to avoid pathological inflamma...
Age affects the immune system more than a moderate surgical trauma and anesthesia
Age affects the immune system more than a moderate surgical trauma and anesthesia
Age affects the immune system more than a moderate surgical trauma and anesthesiaAbstractThe effectiveness of the immune system decreases with increasing age. This process is known as immunosenesce...
Exploring the molecular mechanism of apigenin in treating bronchiectasis based on network pharmacolo
Exploring the molecular mechanism of apigenin in treating bronchiectasis based on network pharmacolo
Exploring the molecular mechanism of apigenin in treating bronchiectasis based on network pharmacology and molecular dockingAbstractBronchiectasis is a complex, heterogeneous inflammatory chronic r...
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80AbstractEndosomal sorting complex required for transport (ESCRT) is the major membrane remodeling co...
Pre-rRNAs control mitosis by maintaining chromosomal segregation through protecting SMC2 from AURKA-
Pre-rRNAs control mitosis by maintaining chromosomal segregation through protecting SMC2 from AURKA-
Pre-rRNAs control mitosis by maintaining chromosomal segregation through protecting SMC2 from AURKA-mediated phosphorylationAbstractIn interphase, 47S pre-rRNA is transcribed by RNA polymerase I (P...
The composition and structure of the outer kinetochore KMN complex is conserved across kingdoms
The composition and structure of the outer kinetochore KMN complex is conserved across kingdoms
The composition and structure of the outer kinetochore KMN complex is conserved across kingdomsAbstractIn eukaryotes, chromosome segregation relies on attachment to the spindle, ensured by the kine...
The use of Janus kinase inhibitors to treat noninfectious uveitis
The use of Janus kinase inhibitors to treat noninfectious uveitis
The use of Janus kinase inhibitors to treat noninfectious uveitisAbstractObjectiveTo present a case series of eight patients with noninfectious chronic uveitis treated at a single institution with ...
Pathogenic drivers of lupus myocarditis and potential therapeutic targets
Pathogenic drivers of lupus myocarditis and potential therapeutic targets
Pathogenic drivers of lupus myocarditis and potential therapeutic targetsAbstractSystemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organs simultaneously, comp...
Circulating endotoxin is correlated with fatty acid binding protein 2 and leukocyte nuclear factor-κ
Circulating endotoxin is correlated with fatty acid binding protein 2 and leukocyte nuclear factor-κ
Circulating endotoxin is correlated with fatty acid binding protein 2 and leukocyte nuclear factor-κB activation in menopausal womenAbstractCirculating endotoxin is mainly derived from gut microbio...
Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive o
Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive o
Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive ovarian cancer: the randomized phase 2 SOLACE2 trialAbstractSOLACE2 (ACTRN12618000686202) investig...
Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammat
Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammat
Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammation against knee osteoarthritis: a randomized, double-blind, placebo-controlled, clinical phase 1...
Aerosol and intranasal delivery of monoclonal antibodies to prevent transmission in pig influenza in
Aerosol and intranasal delivery of monoclonal antibodies to prevent transmission in pig influenza in
Aerosol and intranasal delivery of monoclonal antibodies to prevent transmission in pig influenza infection modelsAbstractThere is an urgent need for robust animal models to assess novel therapies ...
Unravelling the cellular sources and location of IL-17A production during a Giardia infection
Unravelling the cellular sources and location of IL-17A production during a Giardia infection
Unravelling the cellular sources and location of IL-17A production during a Giardia infectionAbstractIL-17A plays a crucial role in the immune defense against Giardia infection, yet its cellular so...
Novel small molecule inhibitor of GPR68 attenuates endothelial dysfunction and lung injury caused by
Novel small molecule inhibitor of GPR68 attenuates endothelial dysfunction and lung injury caused by
Novel small molecule inhibitor of GPR68 attenuates endothelial dysfunction and lung injury caused by bacterial lipopolysaccharideAbstractThe treatment of acute respiratory distress syndrome (ARDS) ...
The tumor microenvironment enhances the expression of cssDNA by modulating cell cycle signaling path
The tumor microenvironment enhances the expression of cssDNA by modulating cell cycle signaling path
The tumor microenvironment enhances the expression of cssDNA by modulating cell cycle signaling pathways via SKP2AbstractCircular single-stranded DNA (cssDNA), an emerging nucleic acid vector, exhi...
Targeting FSP1 triggers ferroptosis in lung cancer
Targeting FSP1 triggers ferroptosis in lung cancer
Targeting FSP1 triggers ferroptosis in lung cancerAbstractEmerging evidence indicates that cancer cells are susceptible to ferroptosis, a form of cell death that is triggered by uncontrolled lipid ...
Spatial single-cell atlas reveals regional variations in healthy and diseased human lung
Spatial single-cell atlas reveals regional variations in healthy and diseased human lung
Spatial single-cell atlas reveals regional variations in healthy and diseased human lungAbstractIntegration of scRNA-seq data from millions of cells revealed a high diversity of cell types in the h...
Thyme oil mitigates cadmium-induced oxidative and genotoxic stress in Vicia faba root meristem cells
Thyme oil mitigates cadmium-induced oxidative and genotoxic stress in Vicia faba root meristem cells
Thyme oil mitigates cadmium-induced oxidative and genotoxic stress in Vicia faba root meristem cells under in vitro conditionsAbstractCadmium is considered one of the most toxic and dangerous envir...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Secretome translation shaped by lysosomes and lunapark-marked ER junctionsAbstractThe endoplasmic reticulum (ER) is a highly interconnected membrane network that serves as a central site for protei...
Bone marrow mesenchymal stem cell exosome-derived miR-223 regulated cellular pyroptosis of macrophag
Bone marrow mesenchymal stem cell exosome-derived miR-223 regulated cellular pyroptosis of macrophag
Bone marrow mesenchymal stem cell exosome-derived miR-223 regulated cellular pyroptosis of macrophage in osteomyelitis through regulating LACC1AbstractOsteomyelitis (OM) is a severe bone infection ...
Human fingertip regeneration follows clinical phases with distinct proteomic signatures
Human fingertip regeneration follows clinical phases with distinct proteomic signatures
Human fingertip regeneration follows clinical phases with distinct proteomic signaturesAbstractDistal injuries in human fingertips can regenerate almost fully, yet the process of human fingertip re...
Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative bre
Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative bre
Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative breast cancerAbstractGangliosides are acidic glycosphingolipids involved in cell-adhesion, signal-tr...
Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and linea
Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and linea
Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and lineage commitmentAbstractConventional human embryonic stem cells (hESCs) are capable of self-renewal ...
Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, op
Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, op
Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, open-label, single-arm, safety trialAbstractLiver transplantation remains constrained by the scarci...
Statistical optimization and scaled-up bioreactor fermentation for enhanced edible oil production fr
Statistical optimization and scaled-up bioreactor fermentation for enhanced edible oil production fr
Statistical optimization and scaled-up bioreactor fermentation for enhanced edible oil production from palm date waste by Rhodotorula glutinis KAEC-61AbstractAgro-industrial residues such as palm d...
Strain-specific activation of aspergillic acid biosynthesis in Aspergillus oryzae NRRL 3483
Strain-specific activation of aspergillic acid biosynthesis in Aspergillus oryzae NRRL 3483
Strain-specific activation of aspergillic acid biosynthesis in Aspergillus oryzae NRRL 3483AbstractAspergillic acid, a hydroxamate-containing pyrazinone derived from leucine and isoleucine, is a ha...
Homeostatic response of phospholipid pathways to PCYT2 deficiency and impaired de Novo synthesis of
Homeostatic response of phospholipid pathways to PCYT2 deficiency and impaired de Novo synthesis of
Homeostatic response of phospholipid pathways to PCYT2 deficiency and impaired de Novo synthesis of phosphatidylethanolamineAbstractPCYT2 is the key regulatory enzyme in the biosynthesis of phospha...
Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous ph
Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous ph
Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and functionAbstractNeonatal encephalopathy caused by hypoxia-ischemia (HI) leads to a st...
Association between smoking status and complete blood cell parameters in baseline data from the Fasa
Association between smoking status and complete blood cell parameters in baseline data from the Fasa
Association between smoking status and complete blood cell parameters in baseline data from the Fasa adults cohort studyAbstractSmoking is one of the most important preventable causes of chronic di...
Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm
Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm
Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid stormAbstractIschemic stroke, a leading cause of global disability and mortality, remains inadequately treated beyo...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector functionAbstractα/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase that maintains ...
The role of coinhibitory receptor-expressing non-T cells in inflammation and immunity: unsung heroes
The role of coinhibitory receptor-expressing non-T cells in inflammation and immunity: unsung heroes
The role of coinhibitory receptor-expressing non-T cells in inflammation and immunity: unsung heroes or peripheral playersAbstractImmune responses are finely regulated by multiple mechanisms, among...
Contribution of the different Neisseria gonorrhoeae lipooligosaccharide structural variants to funct
Contribution of the different Neisseria gonorrhoeae lipooligosaccharide structural variants to funct
Contribution of the different Neisseria gonorrhoeae lipooligosaccharide structural variants to functional responses elicited by GMMA outer membrane vesiclesAbstractDespite decades of research, an e...
The significance and role of the receptor and inflammatory factors in acute respiratory distress syn
The significance and role of the receptor and inflammatory factors in acute respiratory distress syn
The significance and role of the receptor and inflammatory factors in acute respiratory distress syndromeAbstractAcute respiratory distress syndrome (ARDS) is a life-threatening condition character...
Immunogenicity, immune persistence, and safety of japanese encephalitis vaccine schedules among adul
Immunogenicity, immune persistence, and safety of japanese encephalitis vaccine schedules among adul
Immunogenicity, immune persistence, and safety of japanese encephalitis vaccine schedules among adults in Ningxia, ChinaAbstractLive attenuated and vero-cell-inactivated Japanese Encephalitis vacci...
Regulating white blood cell activity through the novel universal receptive system
Regulating white blood cell activity through the novel universal receptive system
Regulating white blood cell activity through the novel universal receptive systemAbstractThe understanding of the mechanisms that control key features of immune cells in various disease contexts re...
Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus ery
Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus ery
Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus erythematosus (SLE) patients from Western IndiaAbstractThe lectin pathway of complement aids in remo...
CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell function
CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell function
CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell functions via CAR-CD28 microclustersAbstractVarious improvements have been made to chimeric antigen recep...
Multi-omic profiling reveals age-related immune dynamics in healthy adults
Multi-omic profiling reveals age-related immune dynamics in healthy adults
Multi-omic profiling reveals age-related immune dynamics in healthy adultsAbstractThe generation and maintenance of immunity is a dynamic process that is dependent on age1,2,3. Here, to better unde...
Leishmania amazonensis infection induces PD-L1 expression on dendritic cells and impairs Th1 respons
Leishmania amazonensis infection induces PD-L1 expression on dendritic cells and impairs Th1 respons
Leishmania amazonensis infection induces PD-L1 expression on dendritic cells and impairs Th1 responses in vitro and in vivoAbstractLeishmania amazonensis is an etiological agent of diffuse cutaneou...
Identification of ferroptosis-related genes in pediatric Crohn’s disease using bioinformatics approa
Identification of ferroptosis-related genes in pediatric Crohn’s disease using bioinformatics approa
Identification of ferroptosis-related genes in pediatric Crohn’s disease using bioinformatics approachesAbstractFerroptosis is increasingly implicated as a critical pathogenic mechanism in inflamma...
hADMSC-YTZP seeding improves peri-implant bone repair through increased expression of BMP-2, ALP, an
hADMSC-YTZP seeding improves peri-implant bone repair through increased expression of BMP-2, ALP, an
hADMSC-YTZP seeding improves peri-implant bone repair through increased expression of BMP-2, ALP, and OPGAbstractDental implant failure is frequently attributed to inadequate Peri-Implant Bone Repa...
Epigenetic dysregulation in aged muscle stem cells drives mesenchymal progenitor expansion via IL-6
Epigenetic dysregulation in aged muscle stem cells drives mesenchymal progenitor expansion via IL-6
AbstractSarcopenia, the age-related decline in muscle mass, strength and function, is characterized by impaired muscle homeostasis, reduced regenerative potential of muscle stem cells (MuSCs) and i...
Ketamine and dodecyl maltoside synergy as a potential topical therapeutic approach for melanoma
Ketamine and dodecyl maltoside synergy as a potential topical therapeutic approach for melanoma
Ketamine and dodecyl maltoside synergy as a potential topical therapeutic approach for melanomaAbstractMelanoma is the most aggressive subtype of skin cancer with limited treatment options due to t...
Evidence for improved DNA repair in long-lived bowhead whale
Evidence for improved DNA repair in long-lived bowhead whale
Evidence for improved DNA repair in long-lived bowhead whaleAbstractAt more than 200 years, the maximum lifespan of the bowhead whale exceeds that of all other mammals. The bowhead is also the seco...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosisAbstractLipid droplets (LDs) are organelles that store and supply lipids, based on cellular needs. Alt...
Ferrite chitosan curcumin nanoparticles alleviate nandrolone decanote induced liver toxicity in male
Ferrite chitosan curcumin nanoparticles alleviate nandrolone decanote induced liver toxicity in male
Ferrite chitosan curcumin nanoparticles alleviate nandrolone decanote induced liver toxicity in male albino ratsAbstractSr2NiCoAl0.3Fe27.7O46 X-Type hexa-nano-ferrites were prepared using a co-prec...
Different immunotherapeutic combinations enhance specific T cell immune responses against leukemic c
Different immunotherapeutic combinations enhance specific T cell immune responses against leukemic c
Different immunotherapeutic combinations enhance specific T cell immune responses against leukemic cells, as well as leukemic progenitor cells, in acute myeloid leukemiaAbstractImmunotherapeutic ap...
Modulation of the blood–brain barrier permeability by patient-derived glioblastoma stem cell secreto
Modulation of the blood–brain barrier permeability by patient-derived glioblastoma stem cell secreto
Modulation of the blood–brain barrier permeability by patient-derived glioblastoma stem cell secretomeAbstractThe blood–brain barrier (BBB) is a highly selective barrier that strictly controls the ...
Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regul
Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regul
Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathwaysAbstractGlioblastoma is the most aggressive and lethal ...
Patient-specific hiPSC-Podocytes as an in vitro model of genetic FSGS
Patient-specific hiPSC-Podocytes as an in vitro model of genetic FSGS
Patient-specific hiPSC-Podocytes as an in vitro model of genetic FSGSAbstractMutations in podocyte-specific genes are associated with genetic focal segmental glomerulosclerosis (FSGS), yet the pote...
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechan
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechan
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loopAbstractWith aging or osteoporosis, bone marrow adipogenesis is incre...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions
Selective RNA sequestration in biomolecular condensates directs cell fate transitions
Selective RNA sequestration in biomolecular condensates directs cell fate transitionsAbstractControlling stem cell differentiation is a longstanding goal in biomedical research. Here we explore how...
Tauroursodeoxycholic acid-induced increase in ectopic muscle mineralization occurs exclusively in dy
Tauroursodeoxycholic acid-induced increase in ectopic muscle mineralization occurs exclusively in dy
Tauroursodeoxycholic acid-induced increase in ectopic muscle mineralization occurs exclusively in dystrophic muscles and is independent of endoplasmic reticulum stressAbstractCalcification of dystr...
Ultrastructural evaluation of lithium-induced autophagic and mitochondrial stress in 3D endometrial
Ultrastructural evaluation of lithium-induced autophagic and mitochondrial stress in 3D endometrial
Ultrastructural evaluation of lithium-induced autophagic and mitochondrial stress in 3D endometrial and neuroblastoma spheroidsAbstractLithium chloride (LiCl), a widely used mood stabilizer, has be...
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activationAbstractThe role of CD8+ tissue-resident memory T (CD8+ TRM) in inflammation is well established. However, ...
Cell autonomous polarization by the planar cell polarity signaling pathway
Cell autonomous polarization by the planar cell polarity signaling pathway
Cell autonomous polarization by the planar cell polarity signaling pathwayAbstractAs epithelial cells polarize in the tissue plane, the Planar Cell Polarity (PCP) signaling module segregates two di...
Multifaceted roles of CARM1 beyond histone arginine methylation
Multifaceted roles of CARM1 beyond histone arginine methylation
Multifaceted roles of CARM1 beyond histone arginine methylationAbstractCoactivator-associated arginine methyltransferase 1 (CARM1), first identified in 1999, has been studied primarily for its nucl...
Exploration of the roles of HLAs when predicting infection status by T cell receptors
Exploration of the roles of HLAs when predicting infection status by T cell receptors
Exploration of the roles of HLAs when predicting infection status by T cell receptorsAbstractT cells are critical components of the human immune system. When a cell is infected by a virus, it prese...
Mapping NK cell diversity in response to COVID-19 and mRNA vaccination
Mapping NK cell diversity in response to COVID-19 and mRNA vaccination
Mapping NK cell diversity in response to COVID-19 and mRNA vaccinationAbstractHuman NK cells exhibit functional heterogeneity, yet the clinical conditions and cellular processes driving this divers...
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activationAbstractThe role of CD8+ tissue-resident memory T (CD8+ TRM) in inflammation is well established. However, ...
Estimating the decay of protective antibodies induced by SARS-CoV-2 mRNA vaccination and hybrid immu
Estimating the decay of protective antibodies induced by SARS-CoV-2 mRNA vaccination and hybrid immu
Estimating the decay of protective antibodies induced by SARS-CoV-2 mRNA vaccination and hybrid immunityAbstractStarting in 2020, we quantified anti-wildtype SARS-CoV-2 spike sera IgG at monthly in...
Cell-engineered technologies for wound healing and tissue regeneration
Cell-engineered technologies for wound healing and tissue regeneration
Cell-engineered technologies for wound healing and tissue regenerationAbstractThis review provides a comprehensive analysis of diverse cell-engineered technologies for wound healing and tissue rege...
Engineered thoracic spinal cord organoids for transplantation after spinal cord injury
Engineered thoracic spinal cord organoids for transplantation after spinal cord injury
Engineered thoracic spinal cord organoids for transplantation after spinal cord injuryAbstractStem-cell-based neural tissue engineering and spinal cord organoids show promises for spinal cord injur...
Combining antigenic data from public sources gives an early indication of the immune escape of emerg
Combining antigenic data from public sources gives an early indication of the immune escape of emerg
Combining antigenic data from public sources gives an early indication of the immune escape of emerging virus variantsAbstractThe rapid spread of the Omicron BA.1 (B.1.1.529.1) SARS-CoV-2 (Severe A...
Combining AlphaFold—based AI docking with omics technologies preliminarily unveils the mechanism of
Combining AlphaFold—based AI docking with omics technologies preliminarily unveils the mechanism of
Combining AlphaFold—based AI docking with omics technologies preliminarily unveils the mechanism of Guominkang in treating allergic rhinitisAbstractAllergic rhinitis (AR) is a common immune-mediate...
N-acetyl-glucosamine primes Pseudomonas aeruginosa for virulence through a type IV pili/cAMP-mediate
N-acetyl-glucosamine primes Pseudomonas aeruginosa for virulence through a type IV pili/cAMP-mediate
N-acetyl-glucosamine primes Pseudomonas aeruginosa for virulence through a type IV pili/cAMP-mediated morphology transitionAbstractA microbe is pathogenic when it manages to survive in its host and...
Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic
Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic
Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic candidiasisAbstractEosinophils are innate immune cells with central roles in allergy, parasitic ...
Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicity
Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicity
Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicityAbstractAcute liver injury often progresses to liver failure, with immune responses playing a critical role in regulati...
Predictive value of PD-1+CD3+ T cells for 30-day mortality in patients with sepsis
Predictive value of PD-1+CD3+ T cells for 30-day mortality in patients with sepsis
Predictive value of PD-1+CD3+ T cells for 30-day mortality in patients with sepsisAbstractIncreased expression of programmed cell death protein-1 (PD-1) on T lymphocyte subsets is associated with s...
Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicity
Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicity
AbstractAcute liver injury often progresses to liver failure, with immune responses playing a critical role in regulating the inflammatory process. In this study, we aim to investigate the effects ...
Changes in the mucosal immunity induced by diets enriched with cocoa and hesperidin in intensively t
Changes in the mucosal immunity induced by diets enriched with cocoa and hesperidin in intensively t
AbstractMucosal immunity can be altered by exhausting exercise, while it may be enhanced by flavonoid-enriched diets. This study aimed both to ascertain the influence of exhausting exercise in rats...
Predictive value of PD-1+CD3+ T cells for 30-day mortality in patients with sepsis
Predictive value of PD-1+CD3+ T cells for 30-day mortality in patients with sepsis
AbstractIncreased expression of programmed cell death protein-1 (PD-1) on T lymphocyte subsets is associated with sepsis immunosuppression and offers potential biomarkers for prognosis. However, fe...
CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblas
CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblas
AbstractGlioblastoma (GBM) remains a formidable challenge in clinical settings due to limited treatments available. The surface protein CD133 marks glioblastoma stem cells (GSCs), cells capable of ...
Distinct roles of amniotic membrane epithelial (hAEC) and mesenchymal stromal cells (hAMSC) in amnio
Distinct roles of amniotic membrane epithelial (hAEC) and mesenchymal stromal cells (hAMSC) in amnio
AbstractHuman skin wound healing is a complex process involving sequential cellular events to restore skin integrity. Chronic wounds fail to heal due to impaired keratinocyte activation and dysregu...
P-selectin overexpression impairs hematopoietic stem cell homeostasis via inflammatory receptor-medi
P-selectin overexpression impairs hematopoietic stem cell homeostasis via inflammatory receptor-medi
AbstractHematopoietic stem cells (HSC) sustain lifelong blood and immune system homeostasis. This study identifies P-selectin as a pivotal regulator of HSC function under aging and inflammatory str...
The genetically encoded biosensor FEOX is a molecular gauge for cellular iron environment dynamics a
The genetically encoded biosensor FEOX is a molecular gauge for cellular iron environment dynamics a
AbstractIron-sensing is evolutionarily conserved among life on Earth, and mammalian cells are known to sense cellular iron through mechanisms similar to bacteria and marine invertebrates. While iro...
Condensate nanovaccine adjuvants augment CD8+ T-Cell-dependent antitumor immunity through mtDNA leak
Condensate nanovaccine adjuvants augment CD8+ T-Cell-dependent antitumor immunity through mtDNA leak
Condensate nanovaccine adjuvants augment CD8+ T-Cell-dependent antitumor immunity through mtDNA leakage-triggered cGAS-STING axis activationAbstractThe variety and functionality of current clinical...
Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial
Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial
Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial fibrillary acidic protein and preventing inflammationAbstractAstrocytes are central to the pathog...
Blood cell biomarker trajectories and depression risk in a sex-stratified 10-year longitudinal cohor
Blood cell biomarker trajectories and depression risk in a sex-stratified 10-year longitudinal cohor
Blood cell biomarker trajectories and depression risk in a sex-stratified 10-year longitudinal cohort analysisAbstractDepression is a global health challenge, and recent attention has been given to...
Plasma proteome adaptations during feminizing gender-affirming hormone therapy
Plasma proteome adaptations during feminizing gender-affirming hormone therapy
Plasma proteome adaptations during feminizing gender-affirming hormone therapyAbstractSex differences manifest in various traits, as well as in the risk of cardiovascular, metabolic and immunologic...
An animal model of NLRC4-associated autoinflammation and infantile enterocolitis reveals novel thera
An animal model of NLRC4-associated autoinflammation and infantile enterocolitis reveals novel thera
An animal model of NLRC4-associated autoinflammation and infantile enterocolitis reveals novel therapeutic strategiesAbstractInflammasomes, particularly NLRC4, play crucial roles in immune response...
A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions
A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions
A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansionsAbstractEffective cancer immunotherapy relies on the clonal proliferation and expansion of CD8+ T cells in the tumor. How...
Eosinophil-derived interleukin-24 compromises epithelial integrity and aggravates airway remodeling
Eosinophil-derived interleukin-24 compromises epithelial integrity and aggravates airway remodeling
Eosinophil-derived interleukin-24 compromises epithelial integrity and aggravates airway remodeling in mouse models of allergic asthmaAbstractAsthma is a heterogeneous disease characterized by infi...
Animal-free alternatives for Matrigel in human iPSC-derived blood vessel organoid culture
Animal-free alternatives for Matrigel in human iPSC-derived blood vessel organoid culture
Animal-free alternatives for Matrigel in human iPSC-derived blood vessel organoid cultureAbstractThe use of blood vessel organoids (BVOs), or vascular organoids derived from human induced pluripote...
Assessment of the safety of hypoxia-primed mesenchymal stem cells derived from umbilical cord and ad
Assessment of the safety of hypoxia-primed mesenchymal stem cells derived from umbilical cord and ad
Assessment of the safety of hypoxia-primed mesenchymal stem cells derived from umbilical cord and adipose tissues in animalsAbstractMesenchymal stem cells (MSCs) are widely used for disease treatme...
CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblas
CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblas
CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastomaAbstractGlioblastoma (GBM) remains a formidable challenge in clinical settings due to limited...
CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction vi
CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction vi
CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibitionAbstractMultiple organ dysfunction syndrome (MODS) claims a life...
αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in
αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in
αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse modelsAbstractAdministration of IL-2 may promote the suppressive function and proliferation...
Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels
Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels
Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panelsAbstractFragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic a...
Th1 and Th2 cells in equine endometrosis and their interactions with endometrial fibroblasts
Th1 and Th2 cells in equine endometrosis and their interactions with endometrial fibroblasts
Th1 and Th2 cells in equine endometrosis and their interactions with endometrial fibroblastsAbstractMare endometrosis is a chronic degenerative condition of the endometrium, primarily characterized...
Efficacy of glucocorticoids treatment in recurrent embryo implantation failure
Efficacy of glucocorticoids treatment in recurrent embryo implantation failure
Efficacy of glucocorticoids treatment in recurrent embryo implantation failureAbstractRecurrent implantation failure (RIF) poses a significant challenge in treating infertility. RIF can stem from v...
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophagesAbstractAccurately tracking dynamic state transitions is crucial for modeling and predicting biolo...
Dendritic cell progenitors engineered to express extracellular-vesicle–internalizing receptors enhan
Dendritic cell progenitors engineered to express extracellular-vesicle–internalizing receptors enhan
Dendritic cell progenitors engineered to express extracellular-vesicle–internalizing receptors enhance cancer immunotherapy in mouse modelsAbstractCancer immunotherapy using dendritic cells (DC) pu...
The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translati
The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translati
The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibitionAbstractRecognition of foreign RNA is critical for the innate immune response to vir...
Pan-Immune-Inflammatory value and risk of latent tuberculosis infection
Pan-Immune-Inflammatory value and risk of latent tuberculosis infection
Pan-Immune-Inflammatory value and risk of latent tuberculosis infectionAbstractTo investigate the association between the Pan-Immune-Inflammatory Value (PIV) and the risk of latent tuberculosis inf...
The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells
The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells
The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cellsAbstractThe co-inhibitory receptor TIGIT suppresses excessive immune responses in autoimmune conditions while also re...
Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled
Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled
Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled phase 1b studyAbstractChronic human immunodeficiency virus type 1 (HIV-1) disease results in immu...
A molecular circuit regulates fate plasticity in emerging and adult AT2 cells
A molecular circuit regulates fate plasticity in emerging and adult AT2 cells
A molecular circuit regulates fate plasticity in emerging and adult AT2 cellsAbstractAlveolar Type 1 and Type 2 cells are vital for lung gas exchange and become compromised in several diseases. Whi...
Cricket protein peptides regulate adipogenic and osteogenic differentiation of human mesenchymal ste
Cricket protein peptides regulate adipogenic and osteogenic differentiation of human mesenchymal ste
Cricket protein peptides regulate adipogenic and osteogenic differentiation of human mesenchymal stem cellsAbstractThe growing global demand for sustainable and nutritious food sources has spurred ...
Genetically tractable embryonic cell lines from sea urchins Lytechinus variegatus and Strongylocentr
Genetically tractable embryonic cell lines from sea urchins Lytechinus variegatus and Strongylocentr
Genetically tractable embryonic cell lines from sea urchins Lytechinus variegatus and Strongylocentrotus purpuratusAbstractSea urchins have been valuable research models for over a century, advanci...
Ptbp1 knockdown induces conversion of rat spinal cord astrocytes into neuron like cells
Ptbp1 knockdown induces conversion of rat spinal cord astrocytes into neuron like cells
Ptbp1 knockdown induces conversion of rat spinal cord astrocytes into neuron like cellsAbstractPolypyrimidine tract-binding protein 1 (Ptbp1) is crucial in regulating neuronal differentiation and m...
Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influ
Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influ
Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza virusesAbstractHighly pathogenic avian influenza H5Nx viruses are an emerging threat for glo...
Pentanoate modulates B cells to suppress allergic contact hypersensitivity
Pentanoate modulates B cells to suppress allergic contact hypersensitivity
Pentanoate modulates B cells to suppress allergic contact hypersensitivityAbstractAllergic contact dermatitis (ACD) is a common T cell-mediated hypersensitivity reaction affecting the skin after ex...
IL-1 family cytokines in inflammation and immunity
IL-1 family cytokines in inflammation and immunity
IL-1 family cytokines in inflammation and immunityAbstractInterleukin-1 (IL-1) was the first interleukin identified as a potent proinflammatory and multifunctional molecule involved in innate immun...
Trained immunity: induction of an inflammatory memory in disease
Trained immunity: induction of an inflammatory memory in disease
Trained immunity: induction of an inflammatory memory in diseaseAbstractThe innate immune system adapts its behavior based on previous insults, mounting an enhanced response upon re-exposure. Hemat...
Identification of genetic variants associated with lupus nephritis in a Taiwanese cohort through sys
Identification of genetic variants associated with lupus nephritis in a Taiwanese cohort through sys
Identification of genetic variants associated with lupus nephritis in a Taiwanese cohort through systematic genetic screeningAbstractLupus nephritis (LN) is a common manifestation of systemic lupus...
B cells induced regulatory T cells attenuated the classical M1 polarization of mouse bone marrow-der
B cells induced regulatory T cells attenuated the classical M1 polarization of mouse bone marrow-der
B cells induced regulatory T cells attenuated the classical M1 polarization of mouse bone marrow-derived macrophagesAbstractRegulatory T (Treg) cells are effective immunomodulators of adaptive and ...
Long-term dynamics of cytomegalovirus-specific antibodies in a longitudinal cohort of children follo
Long-term dynamics of cytomegalovirus-specific antibodies in a longitudinal cohort of children follo
Long-term dynamics of cytomegalovirus-specific antibodies in a longitudinal cohort of children followed up for the first decade of lifeAbstractCytomegalovirus (CMV) causes infections that last a li...
Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promot
Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promot
Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promote anti-viral innate immune evasionAbstractViral strategies to antagonize the robust host innate i...
Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemi
Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemi
Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosusAbstractMesenchymal stromal cell (MSC) transplantation has achieved signific...
Phenotype disruption of umbilical cord derived MSC by cyclic mechanical stretch and hyperoxia mediat
Phenotype disruption of umbilical cord derived MSC by cyclic mechanical stretch and hyperoxia mediat
Phenotype disruption of umbilical cord derived MSC by cyclic mechanical stretch and hyperoxia mediated by p21AbstractPreclinical studies provided convincing evidence that umbilical cord derived mes...
UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation
UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation
UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturationAbstractProtein–lipid crosstalk is fundamental to homeostasis in the endoplasmic reticulum (ER). The ER-asso...
ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard cortico
ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard cortico
ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesisAbstractDespite the numerous pathogenic variants linked to neurodevelopmental disorders (N...
Ddx61-enriched condensates refine heart regeneration programs
Ddx61-enriched condensates refine heart regeneration programs
Ddx61-enriched condensates refine heart regeneration programsAbstractGene regulatory mechanisms that underlie tissue regeneration have been largely studied at the level of transcription. Here, prox...
Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal mening
Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal mening
Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in miceAbstractCryptococcal meningitis is a fungal infection in patients with compromised CD...
Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens a
Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens a
Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patternsAbstractThe inflammasome is an inflammatory signaling protein complex...
Incorporating meningeal immunity into vaccine development
Incorporating meningeal immunity into vaccine development
Incorporating meningeal immunity into vaccine developmentAbstractMeningeal immunity, a less-studied aspect of neuroimmune interactions, has recently come under the spotlight owing to the characteri...
mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangio
mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangio
mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosisAbstractLymphangioleiomyomatosis (LAM) is a rare disease of women in which TSC2 def...
Lactococcus lactis subsp. cremoris C60 promotes immunoglobulin a production from B cells through fun
Lactococcus lactis subsp. cremoris C60 promotes immunoglobulin a production from B cells through fun
Lactococcus lactis subsp. cremoris C60 promotes immunoglobulin a production from B cells through functional modification of dendritic cells in the intestinal environmentAbstractProbiotics utilizing...
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-cateni
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-cateni
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signalingAbstractGlioblastoma (GBM) stem cells (GSCs) are pivotal in tumor initiation, re...
NSUN7-mediated m5C methylation of NLRP3 promotes pyroptosis in ovarian granulosa cells in polycystic
NSUN7-mediated m5C methylation of NLRP3 promotes pyroptosis in ovarian granulosa cells in polycystic
NSUN7-mediated m5C methylation of NLRP3 promotes pyroptosis in ovarian granulosa cells in polycystic ovary syndromeAbstractPyroptosis is a pathogenenic mechanism of polycystic ovary syndrome (PCOS)...
The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vac
The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vac
The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vaccination strategyAbstractGenetically attenuated parasites (GAPs) that arrest during liver stage d...
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulat
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulat
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cellsAbstractRegulatory T (Treg) cells, expressing the transcription factor Foxp3, are obli...
Alpha hemolysin enhances the immune response by modulating dendritic cell differentiation via ADAM10
Alpha hemolysin enhances the immune response by modulating dendritic cell differentiation via ADAM10
Alpha hemolysin enhances the immune response by modulating dendritic cell differentiation via ADAM10-Notch signalingAbstractAlpha hemolysin, a pore-forming toxin from Staphylococcus aureus, is a cr...
Immunoendocrine network under conditions of diabetes-filariasis co-morbidity DMLF6
Immunoendocrine network under conditions of diabetes-filariasis co-morbidity DMLF6
Immunoendocrine network under conditions of diabetes-filariasis co-morbidity DMLF6AbstractChildhood exposure to filariasis can confer significant protection against diabetes which is called as “Met...
Neutralizing antibody durability and SARS-CoV-2 infection in older adults six months after XBB-conta
Neutralizing antibody durability and SARS-CoV-2 infection in older adults six months after XBB-conta
Neutralizing antibody durability and SARS-CoV-2 infection in older adults six months after XBB-containing vaccine boosterAbstractThe persistence of XBB-containing vaccine-induced immunity against e...
Base edited “universal” donor CAR T-cell strategies for acute myeloid leukaemia
Base edited “universal” donor CAR T-cell strategies for acute myeloid leukaemia
Base edited “universal” donor CAR T-cell strategies for acute myeloid leukaemiaAbstractAcute myeloid leukaemia (AML) is often aggressive and life-threatening with limited curative options. Immunoth...
Computational design of an mRNA vaccine targeting antifungal-resistant Lomentospora prolificans
Computational design of an mRNA vaccine targeting antifungal-resistant Lomentospora prolificans
Computational design of an mRNA vaccine targeting antifungal-resistant Lomentospora prolificansAbstractLomentospora prolificans is an emerging opportunistic pathogen that predominantly affects immu...
Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 deliver
Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 deliver
Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 deliveryAbstractChimeric antigen receptor (CAR)-T cell efficacy in solid tumours is limited due in part ...
Long-persisting SARS-CoV-2 spike-specific CD4+ T cells associated with mild disease and increased cy
Long-persisting SARS-CoV-2 spike-specific CD4+ T cells associated with mild disease and increased cy
Long-persisting SARS-CoV-2 spike-specific CD4+ T cells associated with mild disease and increased cytotoxicity post COVID-19AbstractThe recent COVID-19 pandemic left behind the lingering question a...
Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertilit
Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertilit
Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders in miceAbstractGaps in knowledge about the epididymal mucosa contribute to the preval...
Trained immunity induced by DAMPs and LAMPs in chronic inflammatory diseases
Trained immunity induced by DAMPs and LAMPs in chronic inflammatory diseases
Trained immunity induced by DAMPs and LAMPs in chronic inflammatory diseasesAbstractThe immune system has traditionally been divided into innate and adaptive branches, with immunological memory con...
Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice
Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice
Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in riceAbstractSheath blight (ShB), caused by necrotrophic fungus Rhizoctonia solani, is one of the most seriou...
A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammati
A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammati
A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammationAbstractInflammatory bowel disease (IBD) arises from genetic-environmental interactions. Adenos...
HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female maca
HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female maca
HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaquesAbstractSimian or Human immunodeficiency virus (SIV or HIV) vaccines based on V1-deleted enve...
An anti-TSLP monoclonal antibody for uncontrolled CRSwNP: the DUBHE randomized clinical trial
An anti-TSLP monoclonal antibody for uncontrolled CRSwNP: the DUBHE randomized clinical trial
An anti-TSLP monoclonal antibody for uncontrolled CRSwNP: the DUBHE randomized clinical trialAbstractTo explore the therapeutic potential of blocking thymic stromal lymphopoietin (TSLP) in patients...
Macrophage WDFY3 mitigates autoimmunity by enhancing efferocytosis and suppressing T cell activation
Macrophage WDFY3 mitigates autoimmunity by enhancing efferocytosis and suppressing T cell activation
Macrophage WDFY3 mitigates autoimmunity by enhancing efferocytosis and suppressing T cell activation in miceAbstractEfficient efferocytosis is crucial for immune homeostasis. Conversely, excessive ...
Age is an intrinsic driver of inflammatory responses to malaria
Age is an intrinsic driver of inflammatory responses to malaria
Age is an intrinsic driver of inflammatory responses to malariaAbstractAge is a critical factor in immune responses to infection. In malaria, severe disease risk increases with age in non-immune in...
Serotonin 2A receptor attenuates psoriatic inflammation by suppressing IL-23 secretion in monocyte-d
Serotonin 2A receptor attenuates psoriatic inflammation by suppressing IL-23 secretion in monocyte-d
Serotonin 2A receptor attenuates psoriatic inflammation by suppressing IL-23 secretion in monocyte-derived Langerhans cellsAbstractAnecdotal evidence has suggested an association between psychiatri...
Detection of PEG-specific antibodies in SARS-CoV-2 positive and negative sera with implications for
Detection of PEG-specific antibodies in SARS-CoV-2 positive and negative sera with implications for
Detection of PEG-specific antibodies in SARS-CoV-2 positive and negative sera with implications for autoimmune reactivityAbstractPolyethylene glycol (PEG) is a stabilizing polymer that may act as a...
Investigating the role of the ALPK1 signaling pathway in the pathogenesis of diabetic retinopathy
Investigating the role of the ALPK1 signaling pathway in the pathogenesis of diabetic retinopathy
Investigating the role of the ALPK1 signaling pathway in the pathogenesis of diabetic retinopathyAbstractDiabetic retinopathy (DR) is a key eye-related complication linked to diabetes. Chronic infl...
Durability of next-generation self-replicating RNA vaccine RBI-4000: a phase 1, randomized open labe
Durability of next-generation self-replicating RNA vaccine RBI-4000: a phase 1, randomized open labe
Durability of next-generation self-replicating RNA vaccine RBI-4000: a phase 1, randomized open label clinical trialAbstractBackgroundThe benefits of mRNA-based platforms, such as rapid response an...
Autonomous artificial intelligence prescribing a drug to prevent severe acute graft-versus-host dise
Autonomous artificial intelligence prescribing a drug to prevent severe acute graft-versus-host dise
Autonomous artificial intelligence prescribing a drug to prevent severe acute graft-versus-host disease in HLA-haploidentical transplantsAbstractAutonomous artificial intelligence (AI) models for d...
A multivalent mRNA-LNP cocktail vaccine confers superior efficacy against Staphylococcus aureus infe
A multivalent mRNA-LNP cocktail vaccine confers superior efficacy against Staphylococcus aureus infe
A multivalent mRNA-LNP cocktail vaccine confers superior efficacy against Staphylococcus aureus infection in murine modelsAbstractStaphylococcus aureus has been posing a significant global health t...
Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors ne
Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors ne
Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrowAbstractThe formation of Staphylococcus aureus (S....
A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mam
A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mam
A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodesAbstractLymph node (LN) lymphatic endothelial cells (LEC) actively acquire and ...
Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor micro
Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor micro
Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor microenvironmentAbstractChronic inflammation can induce lymphocyte dysfunction, which is characterized...
Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus i
Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus i
Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infectionAbstractInfluenza A virus (IAV) induces ZBP1-mediated PANoptosis, a form of lytic inflamm...
Comprehensive characterization of the molecular feature of acetylation in colorectal cancer using in
Comprehensive characterization of the molecular feature of acetylation in colorectal cancer using in
Comprehensive characterization of the molecular feature of acetylation in colorectal cancer using integrated single-cell and bulk RNA sequencingAbstractColorectal cancer (CRC) remains a major globa...
An immune-competent lung-on-a-chip for modelling the human severe influenza infection response
An immune-competent lung-on-a-chip for modelling the human severe influenza infection response
An immune-competent lung-on-a-chip for modelling the human severe influenza infection responseAbstractSevere influenza affects 3–5 million people worldwide each year, resulting in more than 300,000...
Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders
Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders
AbstractChronic neuroinflammation is a major obstacle to post-stroke recovery, yet the underlying mechanisms, particularly the link between prolonged microglial activation and cholesterol metabolis...
Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjög
Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjög
AbstractSjögren’s disease (SjD) is an autoimmune disease that causes salivary gland dysfunction due to immune-mediated destruction. While autoantibodies such as anti-SSA and anti-centromere (CENT) ...
Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection
Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection
AbstractThe ataxia telangiectasia mutated (ATM) kinase orchestrates the early stages of DNA double-strand break repair by promoting hyperphosphorylation of CtIP, a key step in the initiation of DNA...
Patritumab deruxtecan in HR+HER2− advanced breast cancer: a phase 2 trial
Patritumab deruxtecan in HR+HER2− advanced breast cancer: a phase 2 trial
AbstractAntibody–drug conjugates have shown impressive clinical outcomes, particularly in metastatic breast cancer, but biomarkers to predict response and resistance remain unidentified. Here we re...
Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1
Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1
Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1AbstractIon transport within mitochondria influences their structure, energy production, and cell death regulation. TMBIM5...
Insights in bone marrow failure syndromes: take home messages from the 3rd ESH-EBMT-EHA-IPIG transla
Insights in bone marrow failure syndromes: take home messages from the 3rd ESH-EBMT-EHA-IPIG transla
Insights in bone marrow failure syndromes: take home messages from the 3rd ESH-EBMT-EHA-IPIG translaAbstractBone marrow failure (BMF) syndromes (BMFSs) are a group of disorders characterized by the...
Rewiring interferon fate: a bidirectional strategy for immune homeostasis
Rewiring interferon fate: a bidirectional strategy for immune homeostasis
Rewiring interferon fate: a bidirectional strategy for immune homeostasisIn a recent issue of Nature, Witt and colleagues reveal a chromatin-linked immune checkpoint in which SP140 limits interfero...
Liver immunology: new insights from cutting-edge technologies
Liver immunology: new insights from cutting-edge technologies
Liver immunology: new insights from cutting-edge technologiesIn this article collection, well-established and rising leaders in research related to liver immunology provide their views on the most ...
Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis
Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis
Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosisAbstractLC3-associated phagocytosis (LAP) represents a non-canonical function of autophagy proteins in which ATG...
Macrophage ferroptosis potentiates GCN2 deficiency induced pulmonary venous arterialization
Macrophage ferroptosis potentiates GCN2 deficiency induced pulmonary venous arterialization
Macrophage ferroptosis potentiates GCN2 deficiency induced pulmonary venous arterializationAbstractPulmonary veno-occlusive disease (PVOD) is a fatal disease characterized by the remodelling of pul...
Spatial and functional diversity of innate lymphoid cells in the human female genital tract may cont
Spatial and functional diversity of innate lymphoid cells in the human female genital tract may cont
Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIVAbstractInnate lymphoid cells (ILCs) are tissue-resident lymp...
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regenerationAbstractInterleukin-18 (IL-18) is an acute-phase proinflammatory molecule crucial for mediating viral clearanc...
Cerebral glutamate levels over two years in initially antipsychotic-naïve first-episode patients wit
Cerebral glutamate levels over two years in initially antipsychotic-naïve first-episode patients wit
Cerebral glutamate levels over two years in initially antipsychotic-naïve first-episode patients with psychosis are related to clinical symptoms and cognitionAbstractAlthough emerging evidence supp...
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptorAbstractThe P2X7 receptor is an ATP-gated ion channel that activates inflammatory pathway...
Cranberry improves metabolic syndrome-related organ dysfunction in rats by modulating AMPK/SREBP1, R
Cranberry improves metabolic syndrome-related organ dysfunction in rats by modulating AMPK/SREBP1, R
Cranberry improves metabolic syndrome-related organ dysfunction in rats by modulating AMPK/SREBP1, ROCK1 and TGF-β1AbstractMetabolic syndrome (MetS) is a widespread, complex health issue that poses...
Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis
Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis
Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosisAbstractExcessive consumption of the simple sugar fructose, which induces excessive hepatic lipogenesis an...
Enhancement of antioxidant and antimicrobial properties of Whey protein isolate and chlorogenic acid
Enhancement of antioxidant and antimicrobial properties of Whey protein isolate and chlorogenic acid
Enhancement of antioxidant and antimicrobial properties of Whey protein isolate and chlorogenic acid complexes through enzymatic and alkaline techniquesAbstractThe interactions of whey protein isol...
Co-administration of Spirulina and L-carnitine preserves ovarian reserve in a rat model of premature
Co-administration of Spirulina and L-carnitine preserves ovarian reserve in a rat model of premature
Co-administration of Spirulina and L-carnitine preserves ovarian reserve in a rat model of premature ovarian insufficiency via SIRT1 regulation of oxidative stress, inflammation, and apoptosisAbstr...
Sequential factor delivery enables efficient workflow for universal gene editing in clinical grade i
Sequential factor delivery enables efficient workflow for universal gene editing in clinical grade i
Sequential factor delivery enables efficient workflow for universal gene editing in clinical grade iPS cellsAbstractHuman induced pluripotent stem cells (iPSCs) are gaining momentum as a powerful s...
CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in H
CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in H
CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitnessAbstractGATA2 deficiency is a monogenic transcriptopathy dis...
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory responseAbstractThe formation of membrane pores by cleaved N-terminal gasdermin D (GSDMD-NT) results in the r...
The novel HRD motif kinase SPE-60 is required for sperm development and motility in Caenorhabditis e
The novel HRD motif kinase SPE-60 is required for sperm development and motility in Caenorhabditis e
The novel HRD motif kinase SPE-60 is required for sperm development and motility in Caenorhabditis elegansAbstractSexual reproduction requires sperm development, activation and motility. Many of th...
Post Pandemic Problem, is there an animal model suitable to investigate PASC
Post Pandemic Problem, is there an animal model suitable to investigate PASC
Post Pandemic Problem, is there an animal model suitable to investigate PASCAbstractAlthough the COVID-19 pandemic is no longer a global health emergency, many patients still suffer from long-term ...
Osteogenesis imperfecta, intellectual disability and recurrent infections in a male with a pathogeni
Osteogenesis imperfecta, intellectual disability and recurrent infections in a male with a pathogeni
Osteogenesis imperfecta, intellectual disability and recurrent infections in a male with a pathogenic SASH3 variantAbstractSrc Homology 3 Domain-containing Adaptor Protein 3 (SASH3) deficiency is a...
H2A.Z primes an epigenetic landscape for memory CD8+ T cell recall response
H2A.Z primes an epigenetic landscape for memory CD8+ T cell recall response
AbstractThe rapid recall ability is a hallmark of memory CD8+ T cells, but the underlying mechanisms remain incompletely understood. Here we find that histone variant H2A.Z is expressed at higher l...
Staphyloxanthin loaded niosomal nanocarrier augments its anthelmintic activity against Trichinella s
Staphyloxanthin loaded niosomal nanocarrier augments its anthelmintic activity against Trichinella s
Staphyloxanthin loaded niosomal nanocarrier augments its anthelmintic activity against Trichinella spiralis infection in miceAbstractTrichinellosis, a resurgent zoonotic infestation, threatens publ...
Staphyloxanthin loaded niosomal nanocarrier augments its anthelmintic activity against Trichinella s
Staphyloxanthin loaded niosomal nanocarrier augments its anthelmintic activity against Trichinella s
Staphyloxanthin loaded niosomal nanocarrier augments its anthelmintic activity against Trichinella spiralis infection in miceAbstractTrichinellosis, a resurgent zoonotic infestation, threatens publ...
Effect of maternal COVID-19 vaccination on mandibular molars development in albino rats offspring
Effect of maternal COVID-19 vaccination on mandibular molars development in albino rats offspring
Effect of maternal COVID-19 vaccination on mandibular molars development in albino rats offspringAbstractThe aim of this study was to investigate the effect of maternal vaccination by coronavirus (...
Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremo
Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremo
Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremorAbstractEssential tremor (ET) is a common neurological disease that is characterized by 4–12 Hz ...
Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity
Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity
Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticityAbstractExtracellular matrices of living tissues exhibit viscoelastic properties, yet how these properties re...
Probing the anion binding promiscuity of the soluble nitrate sensor NreA from Staphylococcus carnosu
Probing the anion binding promiscuity of the soluble nitrate sensor NreA from Staphylococcus carnosu
Probing the anion binding promiscuity of the soluble nitrate sensor NreA from Staphylococcus carnosuAbstractPromiscuity, or selectivity on a spectrum, is an encoded feature in biomolecular anion re...
Fluctuating DNA methylation tracks cancer evolution at clinical scale
Fluctuating DNA methylation tracks cancer evolution at clinical scale
Fluctuating DNA methylation tracks cancer evolution at clinical scaleAbstractCancer development and response to treatment are evolutionary processes1,2, but characterizing evolutionary dynamics at ...
BMAL1-TRIM28 represses transposable elements independently of CLOCK in pluripotent cells
BMAL1-TRIM28 represses transposable elements independently of CLOCK in pluripotent cells
BMAL1-TRIM28 represses transposable elements independently of CLOCK in pluripotent cellsAbstractCircadian oscillations of gene transcripts rely on a negative feedback loop executed by the activatin...
Energy deficiency selects crowded live epithelial cells for extrusion
Energy deficiency selects crowded live epithelial cells for extrusion
Energy deficiency selects crowded live epithelial cells for extrusionAbstractEpithelial cells work collectively to provide a protective barrier, yet they turn over rapidly through cell division and...
In vivo itaconate tracing reveals degradation pathway and turnover kinetics
In vivo itaconate tracing reveals degradation pathway and turnover kinetics
In vivo itaconate tracing reveals degradation pathway and turnover kineticsAbstractItaconate is an immunomodulatory metabolite that alters mitochondrial metabolism and immune cell function. This or...
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons
ABCA7 variants impact phosphatidylcholine and mitochondria in neuronsAbstractLoss-of-function variants in the lipid transporter ABCA7 substantially increase the risk of Alzheimer’s disease1,2, yet ...
EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum as
EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum as
EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibilityAbstractCholesterol biosynthesis is more...
Proximity labeling of axonemal protein CFAP91 identifies EFCAB5 that regulates sperm motility
Proximity labeling of axonemal protein CFAP91 identifies EFCAB5 that regulates sperm motility
Proximity labeling of axonemal protein CFAP91 identifies EFCAB5 that regulates sperm motilityAbstractRadial spokes (RSs) are conserved multimolecular structures attached to the axonemal microtubule...
The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human cor
The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human cor
The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronavirusesAbstractIn coronavirus (CoV) infection, polyproteins (pp1a/pp1ab) are processed into no...
m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics
m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics
m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamicsAbstractX-chromosome inactivation (XCI) in mammals is orchestrated by the noncoding RNA X-inactive-specific transcript (...
Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-speci
Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-speci
Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interferenceAbstractAdverse intrauterine environments, such as hyper...
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and meta
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and meta
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolismAbstractThe essential cofactor coenzyme A (CoASH) and its thioester derivatives (acyl-CoAs)...
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic ca
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic ca
Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancerAbstractDurotaxis, cell migration along stiffness gradients, is linked to embryonic developme...
Divergent cytokine and transcriptional signatures control functional T follicular helper cell hetero
Divergent cytokine and transcriptional signatures control functional T follicular helper cell hetero
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneityAbstractCD4+ T follicular helper (TFH) cells support tailored B cell responses against mul...
Direct specification of lymphatic endothelium from mesenchymal progenitors
Direct specification of lymphatic endothelium from mesenchymal progenitors
Direct specification of lymphatic endothelium from mesenchymal progenitorsAbstractDuring embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors te...
STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration
STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration
STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regenerationAbstractThe role of the immune system in regulating tissue stem cells remains poorly understood, as doe...
Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in
Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in
Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in dysferlin-deficient muscular dystrophyAbstractDystrophy-associated fer-1-like protein (dysferlin...
Canonical Wnt signaling regulates Mbd3 protein stability during neurogenesis
Canonical Wnt signaling regulates Mbd3 protein stability during neurogenesis
Canonical Wnt signaling regulates Mbd3 protein stability during neurogenesisAbstractAcquisition of neural progenitor cell (NPC) homeostasis through balancing self-renewal and differentiation is ess...
Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning
Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning
Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterningAbstractIntestinal epithelial cells are segregated into proliferative crypts and differentiated regions. This or...
Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations
Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations
Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutationsAbstractSkin epithelial stem cells correct aberrancies induced by oncogenic mutations. Oncogenes invoke different strateg...
Gliomagenesis mimics an injury response orchestrated by neural crest-like cells
Gliomagenesis mimics an injury response orchestrated by neural crest-like cells
Gliomagenesis mimics an injury response orchestrated by neural crest-like cellsAbstractGlioblastoma is an incurable brain malignancy. By the time of clinical diagnosis, these tumours exhibit a degr...
Reduced adult stem cell fate specification led to eye reduction in cave planarians
Reduced adult stem cell fate specification led to eye reduction in cave planarians
Reduced adult stem cell fate specification led to eye reduction in cave planariansAbstractEye loss occurs convergently in numerous animal phyla as an adaptation to dark environments. We investigate...
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitisAbstractCrohn’s disease pathology is modeled in TNFΔARE+/− mice that overproduce tumor necrosis factor (TNF) to drive diseas...
Conditional generation of real antigen-specific T cell receptor sequences
Conditional generation of real antigen-specific T cell receptor sequences
Conditional generation of real antigen-specific T cell receptor sequencesAbstractDespite recent advances in T cell receptor (TCR) engineering, designing functional TCRs against arbitrary targets re...
The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution
The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution
The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplicationAbstractCopy number control of DNA and centrosomes is essential for accu...
Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive
Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive
Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosisAbstractIn mammals, chromosome-wide regulatory mechanisms ensure a ba...
MDM4 enables efficient human iPS cell generation from PBMCs using synthetic RNAs
MDM4 enables efficient human iPS cell generation from PBMCs using synthetic RNAs
MDM4 enables efficient human iPS cell generation from PBMCs using synthetic RNAsAbstractIf iPS cells can be established easily and efficiently using freshly collected blood cells, it will enhance r...
RNA-binding proteins mediate the maturation of chromatin topology during differentiation
RNA-binding proteins mediate the maturation of chromatin topology during differentiation
RNA-binding proteins mediate the maturation of chromatin topology during differentiationAbstractTopologically associating domains (TADs) and chromatin architectural loops impact promoter–enhancer i...
Elevated SGK1 increases Tau phosphorylation and microtubule instability in Alzheimer’s patient-deriv
Elevated SGK1 increases Tau phosphorylation and microtubule instability in Alzheimer’s patient-deriv
Elevated SGK1 increases Tau phosphorylation and microtubule instability in Alzheimer’s patient-derived cortical neuronsAbstractHyperphosphorylation of Tau and the ensuing microtubule destabilizatio...
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in can
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in can
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cellsAbstractCancer cells are exposed to diverse metabolites in the tumour microenvironment t...
Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervo
Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervo
Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervous systemAbstractConventional understanding dictates that mammalian neural stem cells (NSCs) exis...
Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated
Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated
Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitorsAbstractEndocrine islet β cells comprise heterogenous subtypes with different g...
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regenerationAbstractThe muscle stem cell niche is well-described as influencing myogenic cell fate decision; ...
Echs1-mediated histone crotonylation facilitates zygotic genome activation and expression of repetit
Echs1-mediated histone crotonylation facilitates zygotic genome activation and expression of repetit
Echs1-mediated histone crotonylation facilitates zygotic genome activation and expression of repetitive elements in early mammalian embryosAbstractHistone crotonylation, a conserved post-translatio...
Epitenon-derived progenitors drive fibrosis and regeneration after flexor tendon injury in a spatial
Epitenon-derived progenitors drive fibrosis and regeneration after flexor tendon injury in a spatial
Epitenon-derived progenitors drive fibrosis and regeneration after flexor tendon injury in a spatially-dependent mannerAbstractFlexor tendon injuries are common and heal poorly owing to both the de...
Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function
Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function
Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial functionAbstractAged hematopoietic stem cells (HSCs) exhibit diminished self-renewal and myeloid-biased di...
Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-th
Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-th
Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemiaAbstractThe hematopoietic stem cell and multipotent progenitor (HSC/MPP) pool dynamicall...
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosisAbstractAging is characterized by a decline in the functionality and number of stem cells across the organism...
Detecting and quantifying clonal selection in somatic stem cells
Detecting and quantifying clonal selection in somatic stem cells
Detecting and quantifying clonal selection in somatic stem cellsAbstractAs DNA variants accumulate in somatic stem cells, become selected or evolve neutrally, they may ultimately alter tissue funct...
Magnetic activation of spherical nucleic acids enables the remote control of synthetic cells
Magnetic activation of spherical nucleic acids enables the remote control of synthetic cells
Magnetic activation of spherical nucleic acids enables the remote control of synthetic cellsAbstractThe flexible and modular design of synthetic cells, comprising lipid vesicles capable of imitatin...
Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applicati
Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applicati
Self-assembled DNA nanocarrier-enabled drug delivery for bone remodeling and antimicrobial applicationsAbstractWe report a synthetic tetrahedral DNA nanocarrier (TDN) for treating bone defects and ...
Atomic resolution structures of the methane-activating enzyme in anaerobic methanotrophy reveal exte
Atomic resolution structures of the methane-activating enzyme in anaerobic methanotrophy reveal exte
Atomic resolution structures of the methane-activating enzyme in anaerobic methanotrophy reveal extensive post-translational modificationsAbstractAnaerobic methanotrophic archaea (ANME) are crucial...
Kinase interaction analysis predicts actions of the WNK-OSR1/SPAK pathway
Kinase interaction analysis predicts actions of the WNK-OSR1/SPAK pathway
Kinase interaction analysis predicts actions of the WNK-OSR1/SPAK pathwayAbstractThe WNK-OSR1/SPAK protein kinase pathway regulates ion homeostasis and cell volume, but its other functions are not ...
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryot
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryot
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotesAbstractBase editors create precise genomic edits by directing nucleobase deamination or remova...
Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte developm
Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte developm
Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte developmentAbstractDouble-strand breaks represent the most dangerous form of DNA damage, and in resting c...
KH–R3H domain cooperation in RNA recognition by the global RNA-binding protein KhpB
KH–R3H domain cooperation in RNA recognition by the global RNA-binding protein KhpB
KH–R3H domain cooperation in RNA recognition by the global RNA-binding protein KhpBAbstractKhpB, also known as EloR, is a recently discovered global RNA-binding protein in various pathogenic bacter...
Unified mass imaging maps the lipidome of vertebrate development
Unified mass imaging maps the lipidome of vertebrate development
Unified mass imaging maps the lipidome of vertebrate developmentAbstractEmbryo development entails the formation of anatomical structures with distinct biochemical compositions. Compared with the w...
tRNA as an assembly chaperone for a macromolecular transcription-processing complex
tRNA as an assembly chaperone for a macromolecular transcription-processing complex
tRNA as an assembly chaperone for a macromolecular transcription-processing complexAbstractTransfer RNAs (tRNAs) are widely recognized for their role in translation. Here, we describe a previously ...
SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation
SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation
SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscapeAbstractSOX2 is a potent oncodriver for various squamous cancers, but the underlying mec...
NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo
NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo
NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivoAbstractCurrent colorectal cancer mouse models either lack colon specificity, limiting progression towar...
Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility
Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility
Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility in SMARCA4-deficient NSCLCAbstractFerroptosis, an iron-dependent form of cell death, holds promis...
Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitro
Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitro
Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitroAbstractThe retinal photopigment melanopsin is also expressed in subcutaneous white adipose tissue (scWAT). Thr...
TRIM29 promotes bladder cancer invasion by regulating the intermediate filament network and focal ad
TRIM29 promotes bladder cancer invasion by regulating the intermediate filament network and focal ad
TRIM29 promotes bladder cancer invasion by regulating the intermediate filament network and focal adhesionAbstractBladder cancer is a common malignancy whose lethality is determined by invasive pot...
ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysi
ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysi
ECD, a novel androgen receptor target promotes prostate cancer tumorigenesis by regulating glycolysisAbstractAndrogen receptor (AR)-mediated signaling is essential for PC tumorigenesis. In the TCGA...
Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue
Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue
AbstractBrown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivat
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivat
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivationAbstractAging is a major risk factor for neurodegenerative diseases associated with protein ag...
DNA2 enables growth by restricting recombination-restarted replication
DNA2 enables growth by restricting recombination-restarted replication
DNA2 enables growth by restricting recombination-restarted replicationAbstractNuclease–helicase DNA2 is a multifunctional genome caretaker that is essential for cell proliferation in a range of org...
Single cell resolution 3D imaging and segmentation within intact live tissues
Single cell resolution 3D imaging and segmentation within intact live tissues
Single cell resolution 3D imaging and segmentation within intact live tissuesAbstractEpithelial cells form diverse structures, from squamous spherical organoids to densely packed pseudostratified f...
The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migrat
The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migrat
The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migratory plasticityAbstractWhile migratory cells can quickly change their mode of migration in complex...
Interstitial fluid transport dynamics predict glioblastoma invasion and progression
Interstitial fluid transport dynamics predict glioblastoma invasion and progression
Interstitial fluid transport dynamics predict glioblastoma invasion and progressionAbstractGlioblastoma is characterized by aggressive infiltration into surrounding brain tissue, hindering complete...
Discovery of core genes for systemic lupus erythematosus via genome-wide aggregated trans-effects an
Discovery of core genes for systemic lupus erythematosus via genome-wide aggregated trans-effects an
Discovery of core genes for systemic lupus erythematosus via genome-wide aggregated trans-effects analysisAbstractThe “omnigenic” hypothesis postulates that the polygenic effects of common variants...
NSs: the multifaceted bunyavirus virulence factor
NSs: the multifaceted bunyavirus virulence factor
NSs: the multifaceted bunyavirus virulence factorAbstractBunyaviricetes represents a diverse class of RNA viruses, including hundreds of species distributed worldwide that threaten human and animal...
Regulated cell death in fungi from a comparative immunology perspective
Regulated cell death in fungi from a comparative immunology perspective
Regulated cell death in fungi from a comparative immunology perspectiveAbstractThe death of fungal cells has been studied in a variety of contexts including responses to antifungal drugs, during fu...
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2AbstractThe nine human herpesviruses, including herpes simplex virus 1 and 2, human cytomegalovirus and Epstein–Barr virus...
Reproducible single-cell annotation of programs underlying T cell subsets, activation states and fun
Reproducible single-cell annotation of programs underlying T cell subsets, activation states and fun
Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functionsAbstractT cells recognize antigens and induce specialized gene expression programs (GEPs), ...
Klotho protein alleviates heart ischemia/reperfusion injury and oxidative stress through regulation
Klotho protein alleviates heart ischemia/reperfusion injury and oxidative stress through regulation
Klotho protein alleviates heart ischemia/reperfusion injury and oxidative stress through regulation of the NOS/MMP pathwayAbstractHeart ischemia/reperfusion injury (IRI) significantly contributes t...
Progressive changes in phenotype, transcriptome and proliferation capacity characterise continued ma
Progressive changes in phenotype, transcriptome and proliferation capacity characterise continued ma
Progressive changes in phenotype, transcriptome and proliferation capacity characterise continued maturation and migration of intestinal cDCs in homeostasisAbstractConventional dendritic cells (cDC...
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related in
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related in
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammationAbstractAge-related inflammation or ‘inflammaging’ increases disease burden and control...
Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’
Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’
Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’s diseaseAbstractBehçet’s disease (BD) is a life-threatening systemic vasculitis characterized by...
Distinct circulating autoantibodies are associated with COVID-19 hospitalization and SARS-CoV-2 neut
Distinct circulating autoantibodies are associated with COVID-19 hospitalization and SARS-CoV-2 neut
Distinct circulating autoantibodies are associated with COVID-19 hospitalization and SARS-CoV-2 neutralization activityAbstractSARS-CoV-2 infection disrupts the host’s immune system, altering autoi...
Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets
Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets
Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets into the metastatic melanoma tumor microenvironmentAbstractBackgroundImmune checkpoint inhibitio...
Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential
Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential
Protein lipoylation in cancer: metabolic reprogramming and therapeutic potentialAbstractProtein lipoylation, a mitochondria-specific post-translational modification (PTM) evolutionarily conserved f...
Autism-related proteins form a complex to maintain the striatal asymmetry in mice
Autism-related proteins form a complex to maintain the striatal asymmetry in mice
Autism-related proteins form a complex to maintain the striatal asymmetry in miceAbstractThe brain’s hemispheres exhibit profound lateralization, yet the underlying mechanisms remain elusive. Using...
Loss of PCAF in proximal tubular cells exacerbates renal fibrosis by promoting partial epithelial-to
Loss of PCAF in proximal tubular cells exacerbates renal fibrosis by promoting partial epithelial-to
Loss of PCAF in proximal tubular cells exacerbates renal fibrosis by promoting partial epithelial-to-mesenchymal transitionAbstractRenal fibrosis is a consequence of chronic kidney disease, which i...
Eicosapentaenoic acid restores inflammation-induced changes in chondrocyte mechanics by suppressing
Eicosapentaenoic acid restores inflammation-induced changes in chondrocyte mechanics by suppressing
Eicosapentaenoic acid restores inflammation-induced changes in chondrocyte mechanics by suppressing the NF-κB p65/CD44 signaling pathway and attenuates osteoarthritisAbstractHere we investigate the...
Interactions between the genome and the nuclear lamina are multivalent and cooperative
Interactions between the genome and the nuclear lamina are multivalent and cooperative
Interactions between the genome and the nuclear lamina are multivalent and cooperativeAbstractLamina-associated domains (LADs) are megabase-sized genomic regions that interact with the nuclear lami...
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptationAbstractEndoplasmic reticulum unfolded protein responses contribute to cancer development, with activat...
Chromatin dynamics and regulatory drivers of hypoplastic hepatic progenitor cells in partial hepatec
Chromatin dynamics and regulatory drivers of hypoplastic hepatic progenitor cells in partial hepatec
Chromatin dynamics and regulatory drivers of hypoplastic hepatic progenitor cells in partial hepatectomy modelAbstractThe remarkable plasticity of hepatocytes underlies diverse roles in distinct pa...
The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration
The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration
The Notch ligand Jagged1 plays a dual role in cochlear hair cell regenerationAbstractHair cells within the inner ear cochlea are specialized mechanoreceptors required for hearing. Hair cells are no...
Association of CD14 rs2569190 and rs2569191 polymorphisms with tuberculosis susceptibility in the Ku
Association of CD14 rs2569190 and rs2569191 polymorphisms with tuberculosis susceptibility in the Ku
Association of CD14 rs2569190 and rs2569191 polymorphisms with tuberculosis susceptibility in the Kurdish population of IranAbstractTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), re...
AEBP1 drives fibroblast-mediated T cell dysfunction in tumors
AEBP1 drives fibroblast-mediated T cell dysfunction in tumors
AEBP1 drives fibroblast-mediated T cell dysfunction in tumorsAbstractT cell dysfunction enables tumor immune evasion, understanding its mechanism is crucial for improving immunotherapy. Here we sho...
Immune-coagulation dynamics in severe COVID-19 revealed by autoantibody profiling and multi-omics in
Immune-coagulation dynamics in severe COVID-19 revealed by autoantibody profiling and multi-omics in
Immune-coagulation dynamics in severe COVID-19 revealed by autoantibody profiling and multi-omics integrationAbstractSevere COVID-19 is characterized by immune-coagulation dysregulation, yet the co...
AI-driven epitope prediction: a system review, comparative analysis, and practical guide for vaccine
AI-driven epitope prediction: a system review, comparative analysis, and practical guide for vaccine
AI-driven epitope prediction: a system review, comparative analysis, and practical guide for vaccine developmentAbstractIntegrating AI into epitope prediction is transforming vaccine design by deli...
Histamine as a mediator of cross-talk between human lung mast cells and macrophages
Histamine as a mediator of cross-talk between human lung mast cells and macrophages
Histamine as a mediator of cross-talk between human lung mast cells and macrophagesAbstractHistamine, a multifaceted inflammatory mediator released from mast cells and basophils, has long been reco...
Bioactive compounds in the modulation of oxidative stress in monocytes and macrophages
Bioactive compounds in the modulation of oxidative stress in monocytes and macrophages
Bioactive compounds in the modulation of oxidative stress in monocytes and macrophagesAbstractHuman immunity involves both innate and adaptive defence mechanisms, with inflammation playing a centra...
Sex hormones regulate the sexual dimorphism of the lung resident immune milieu
Sex hormones regulate the sexual dimorphism of the lung resident immune milieu
Sex hormones regulate the sexual dimorphism of the lung resident immune milieuAbstractA strong sex-bias characterizes many respiratory immune diseases and has been attributed to sexually dimorphic ...
Targeting immunosenescence and inflammaging: advancing longevity research
Targeting immunosenescence and inflammaging: advancing longevity research
Targeting immunosenescence and inflammaging: advancing longevity researchAbstractHere we examine the crucial role of the immune system in aging, with a particular focus on two interconnected proces...
Th17 cell pathogenicity in autoimmune disease
Th17 cell pathogenicity in autoimmune disease
Th17 cell pathogenicity in autoimmune diseaseAbstractT helper 17 (Th17) cells have been implicated in numerous inflammatory autoimmune diseases. Clinical benefits from targeting Th17 cell-related c...
A psoriasis cure could be in touching distance
A psoriasis cure could be in touching distance
For people with moderate to severe psoriasis, highly targeted antibody-based treatments introduced in the past 10–15 years have been life changing. Inflamed skin covering swathes of the body often ...
The antitumor effect of tlr4 inhibition in head and neck cancer cell lines
The antitumor effect of tlr4 inhibition in head and neck cancer cell lines
The antitumor effect of tlr4 inhibition in head and neck cancer cell linesAbstractHead and neck cancers (HNC) are a group of heterogeneous tumors frequently associated with high-risk HPV or TP53 mu...
Influenza vaccine strain selection with an AI-based evolutionary and antigenicity model
Influenza vaccine strain selection with an AI-based evolutionary and antigenicity model
Influenza vaccine strain selection with an AI-based evolutionary and antigenicity modelAbstractCurrent vaccines provide limited protection against rapidly evolving viruses. For example, Centers for...
Molecular basis of potent antiviral HLA-C-restricted CD8+ T cell response to an immunodominant SARS-
Molecular basis of potent antiviral HLA-C-restricted CD8+ T cell response to an immunodominant SARS-
Molecular basis of potent antiviral HLA-C-restricted CD8+ T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitopeAbstractThe emergence of SARS-CoV-2 Variants of Concern (VOC) is a majo...
HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation
HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation
HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammationAbstractElimination of apoptotic neutrophils by macrophages, a process called efferocytosis, is a critical s...
B-vac a robust software package for bacterial vaccine design
B-vac a robust software package for bacterial vaccine design
B-vac a robust software package for bacterial vaccine designAbstractReverse Vaccinology (RV) has revolutionized vaccine discovery, utilizing bioinformatics to surpass traditional methods in identif...
DJ-1 counteracts Caveolin-1-mediated necroptosis to inhibit epithelial barrier dysfunction in coliti
DJ-1 counteracts Caveolin-1-mediated necroptosis to inhibit epithelial barrier dysfunction in coliti
DJ-1 counteracts Caveolin-1-mediated necroptosis to inhibit epithelial barrier dysfunction in colitisAbstractCaveolin-1 (CAV1), a pivotal protein implicated in endothelial cell-mediated angiogenesi...
Thymoquinone mediated hedgehog pathway activation and gut microbiota modulation in mouse colitis
Thymoquinone mediated hedgehog pathway activation and gut microbiota modulation in mouse colitis
Thymoquinone mediated hedgehog pathway activation and gut microbiota modulation in mouse colitisAbstractTo investigate the treatment of ulcerative colitis by thymoquinone (TQ) through the Hedgehog ...
IFN-β and ARTS deficiency promote the generation of hyper-efferocytic Ly6C+ macrophages in resolving
IFN-β and ARTS deficiency promote the generation of hyper-efferocytic Ly6C+ macrophages in resolving
IFN-β and ARTS deficiency promote the generation of hyper-efferocytic Ly6C+ macrophages in resolving inflammation in male miceAbstractDuring the resolution of inflammation, Ly6C+F4/80- monocytes di...
The impact of social determinants of health on outcomes of brexucabtagene autoleucel in adults with
The impact of social determinants of health on outcomes of brexucabtagene autoleucel in adults with
The impact of social determinants of health on outcomes of brexucabtagene autoleucel in adults with relapsed/refractory B-cell acute lymphoblastic leukemiaAbstractBrexucabtagene autoleucel (brexu-c...
Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neur
Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neur
Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neuroprotection in neuroinflammationAbstractMultiple Sclerosis (MS), an autoimmune disorder, is chara...
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adultsAbstractAs intrinsic differences in humoral immune response to SARS-CoV-2 between children and adul...
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