Transitioning from native to synthetic receptors: broadening T-cell engineering and beyondAbstractT-cell immunotherapy has progressed rapidly, evolving from native T-cell receptor biology to the de...

Gasdermin E deficiency limits inflammation and lung damage during influenza virus infectionAbstractSevere influenza A virus (IAV) infections are associated with hyperinflammation and significant lu...

Identifying T cell antigen at the atomic level with graph convolutional networkAbstractPrecise identification of T cell antigens in silico is crucial for the development of cancer mRNA vaccines. Ho...

CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cellsAbstractChimeric antigen receptor (CAR) natural killer (NK) cell immunotherapy offers a promising approach against cancer1,2,3...

Immunometabolism of regulatory T cells in cancerAbstractRegulatory T (Treg) cells play critical roles in maintaining immune tolerance and tissue homeostasis, but impede anti-tumor immunity. Recent ...