Uncovering the acetylation sites of Dnmt3L that regulate protein stability and differentiation poten
Uncovering the acetylation sites of Dnmt3L that regulate protein stability and differentiation potency in embryonic stem cellsAbstractThe epigenetic status, which regulates the cellular identity an...
The short-chain fatty acid butyrate prevents gut-brain amyloid-β pathology and neuroinflammation in an Alzheimer mouse modelAbstractAmyloid-β (Aβ) plays a critical role in Alzheimer’s disease (AD) ...
The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinationsAbstractThe clinical success of cancer drug candidates depends...
Tumor cell villages define the co-dependency of tumor and microenvironment in liver cancerAbstractSpatial cellular context is crucial in shaping intratumor heterogeneity. However, understanding how...
Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant propertiesAbstractIncreased extracellular matrix deposition and stiffness promotes solid tumour progression. Yet, th...
Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose–mesenchymal trans
Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose–mesenchymal transformationAbstractAlthough peritumoural visceral adipose tissue (tVAT) is anatomically close to tu...
Drug-controlled CAR T cells through the regulation of cell–cell interactionsAbstractChimeric antigen receptor (CAR) T cell therapy is constrained by on-target, off-tumor toxicities and cellular exh...
HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinomaAbstractInitiation and sustainment of oncogenic signaling is a hallmark of cancer evolution and pro...
The integrated stress response promotes immune evasion through lipocalin 2AbstractCancer cells activate the integrated stress response (ISR) to adapt to stress and resist therapy1. ISR signals conv...
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBCAbstractTriple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. He...
A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinant
A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classificationAbstractClassification of tumors in neuro-oncolog...
Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor respo
Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor responseAbstractAntibodies targeting TGF-β and PD-L1 initially showed promise as second-generation PD-...
Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-depe
Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinomaAbstractGATA6 promotes epithelial phenot...
Extracellular matrix mediates circulating tumor cell clustering in triple-negative breast cancer met
Extracellular matrix mediates circulating tumor cell clustering in triple-negative breast cancer metastasisAbstractMetastatic tumor cell dissemination is the leading cause of cancer-related deaths....
A foundation model for breast and lung cancer screening using non-contrast computed tomographyAbstractCancer screening can enable early detection and improve survival but a focus on single cancers ...
A generalizable foundation model for analysis of human brain MRIAbstractArtificial intelligence applied to brain magnetic resonance imaging (MRI) holds potential to advance diagnosis, prognosis and...
Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with th
Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseasesAbstractThyroid diseases are common and highly heritable....
Activated ATF6α is a hepatic tumour driver restricting immunosurveillanceAbstractHepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality and there are limited therap...
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymp
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodesAbstractImmune checkpoint blockade (ICB) evokes antitumor immunity through the reinvigorat...
2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunityAbstractRecognition of RNA fragments by Toll-like receptor 7 (TLR7) and TLR8 helps to initiate the innate immune re...
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymp
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodesAbstractImmune checkpoint blockade (ICB) evokes antitumor immunity through the reinvigorat...
Epitope mapping of vaccine antigens Tc24 and TSA1 with antibodies from Trypanosoma cruzi-infected pa
Epitope mapping of vaccine antigens Tc24 and TSA1 with antibodies from Trypanosoma cruzi-infected patientsAbstractChagas disease is a zoonotic disease caused by Trypanosoma cruzi parasites. Tc24 an...
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalingAbstractCTNNB1, the gene encoding β-catenin, is a frequent target for oncogenic mutations activating the cano...
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a target
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretomeAbstractPlatinum-based chemotherapy is commonly used for non-small c...
DOT1L provides transcriptional memory through PRC1.1 antagonismAbstractDOT1L and Menin are essential cofactors for the oncogenic activity of MLL fusion proteins (MLL-FPs) in leukaemia. However, the...
Childhood brain tumors instruct cranial hematopoiesis and immunotoleranceAbstractRecent research has challenged a long-held view of the brain as an immune-privileged organ, revealing active immunos...
Endothelial stem cells of the retinal vasculature reside in the optic nerveAbstractCells of the retina, photoreceptors especially, are highly metabolically active with substantial energy requiremen...
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogrammingAbstractSpatiotemporal changes in the nuclear lamina and cell metabolism shape cell fate, yet the...
Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome fo
Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome foldingAbstractEpigenetic memory enables the propagation of gene expression patterns following tran...
Viral mimicry acts as a tumor suppressor in colitisAbstractTransposable elements (TEs) comprising nearly 50% of the genome are generally silenced by epigenetic mechanisms. Epigenetic anti-cancer dr...
CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalize
CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammationAbstractFoxp3-expressing regulatory T (Treg) cells protect against systemic aut...
Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals sp
Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC)AbstractImmune...
Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trialAbstractAntibody-secreting cells (ASCs) play a central role in the pathophysiology of systemic lupus erythematosus (SLE). This...
The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TH2 to TH17 cell c
The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TH2 to TH17 cell conversion via interleukin-4-STAT5 axis in miceAbstractMultiple sclerosis (MS) is a neurodegenerat...
Small intracellular vesicles outperform small extracellular vesicles in uptake, drug delivery and re
Small intracellular vesicles outperform small extracellular vesicles in uptake, drug delivery and retinal neuroprotectionAbstractSmall extracellular vesicles have been widely studied for their ther...
A scalable two-step genome editing strategy for generating full-length gene-humanized mice at divers
A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic lociAbstractFull-length gene-humanized mice engineered by completely replacing mouse lo...
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeleta
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cellsAbstractLoss of Fibronectin (FN) from the skeletal muscle stem cell (MuSC) nic...
Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cellsAbstractBiomechanical alterations contribute to the decreased regenerative capacity of hematopoietic stem cells (HSCs...
H2AK119ub dynamics control hair follicle stem cell quiescenceAbstractAdult stem cells (SCs) transition between quiescent and active states to maintain tissue integrity, and dysregulation of this ba...
Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion
Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversionAbstractThe ability of adult epithelial cells to rewire their cell fate programme in response to ...
METTL3 safeguards cell identity and epigenome of human trophoblast stem cellsAbstractN6-methyladenosine (m6A) is the most prevalent RNA modification and plays diverse roles in mammalian cells. Howe...
Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune di
Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in miceAbstractAutoimmune diseases (AIDs), such as psoriasis and rheumatoid arthritis, are...
CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p2
CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 inductionAbstractCyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine t...
The Knowledge Connector decision support system for multiomics-based precision oncologyAbstractPrecision cancer medicine aims to improve patient outcomes by providing individually tailored recommen...
NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stem
NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemiaAbstractRNA modification has emerged as an important epigenetic me...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44AbstractThe movement of dendritic cells and T cells within secondary lymphoid organs is critical for the development o...
Epoxy-oxylipins direct monocyte fate in inflammatory resolution in humansAbstractThe role of cytochrome P450-derived epoxy-oxylipins and their metabolites in human inflammation and resolution is un...
A multidimensional workflow profiling of allogeneic virus-specific T cell therapies reveals potency-
A multidimensional workflow profiling of allogeneic virus-specific T cell therapies reveals potency-linked signaturesAbstractAllogeneic virus-specific T cell (VST) therapies offer distinct advantag...
Two-year persistence of MERS-CoV-specific antibody and T cell responses after MVA-MERS-S vaccination
Two-year persistence of MERS-CoV-specific antibody and T cell responses after MVA-MERS-S vaccination in healthy adultsAbstractMVA-MERS-S, a vaccine candidate against Middle East respiratory syndrom...
Spatiotemporal regulation of energetic charge dictates T cell functionAbstractImmune cell functions are dictated by their differentiation state and regulated by transcriptional and epigenetic chang...
RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b+ Bregs thereby overcoming melanoma PD1-resistanceAbstractDevelopment of effective second-line treatment options ...
Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leuk
Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemiaAbstractAs part of canonical Wnt signaling, T cell factor (TCF)–β-catenin complexes promote M...
SOX2 confers tumour permissiveness in a specific skin progenitor populationAbstractThe continuous renewal of the skin relies on stem and progenitor cells, yet their differential susceptibility to o...
TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strengthAbstractT-cell avidity is a major determinant of Adoptive T cell therapy (ACT)...
Nutrient requirements of organ-specific metastasis in breast cancerAbstractCancer metastasis is a major contributor to patient morbidity and mortality1, yet the factors that determine the organs wh...
SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to
SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancerAbstractTumour-associated macrophages (TAMs) contribu...
Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cel
Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populationsAbstractGlioblastoma (GBM) remains the most common and lethal adult malignant primar...
Engineered outer membrane vesicles enhance solid tumour CAR-T cell therapyAbstractMajor challenges facing chimeric antigen receptor (CAR)-T cell therapy for solid tumours include the immunosuppress...
Soluble MAdCAM-1 as a biomarker in metastatic renal cell carcinomaAbstractPatients with metastatic renal cell carcinoma treated with immune checkpoint inhibitors or antiangiogenic tyrosine kinase i...
Tumor agnostic drug delivery with dynamic nanohydrogelsAbstractRNA interference (RNAi) holds unique potential as a clinically viable modality to pharmacologically regulate oncogenes in sequence-spe...
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammationAbstractInflammatory activity during multiple sclerosis (MS) often improves during pregnancy, suggesting that pregna...
Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and functionAbstractThe E3 ubiquitin ligase Casitas B-lineage lymphoma (CBL) promotes...
Microglial CX3CR1 deficiency regulates the selective vulnerability of cone photoreceptors via STAT3/
Microglial CX3CR1 deficiency regulates the selective vulnerability of cone photoreceptors via STAT3/CCL–ACKR1 signaling in the mouse retinaAbstractSelective neuronal vulnerability is a common featu...
Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trialAbstractCancer interception is a preventative approach aiming to reduce cancer incidence by targeting...
The aryl hydrocarbon receptor: structure, signaling, physiology and pathologyAbstractThe aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor of the bHLH/PAS protein family. I...
Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy
Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapyAbstractAdoptive T cell therapies are limited by poor persistence of transferred cells. Attempts ...
Strong constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes mic
Strong constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironmental dependenciesAbstractAberrant activation of NF-κB transcription factors is a hallm...
BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cellsAbstractStem-like T cells promote the efficacy of immunotherapy and are heterogeneous in stemness,...
DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentationAbstractAging and DNA damage increase the risk of chronic inflammation and autoimmunity, yet the molecular und...
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthrit
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritisAbstractTreatment-refractory rheumatoid arthritis (RA) is a major unmet need, and the underlyin...
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsisAbstractMetabolic and immunologic dysfunction, including pathological CD4+ T c...
Intranasal replicon vaccine establishes mucosal immunity and protects against H5N1 and H7N9 influenz
Intranasal replicon vaccine establishes mucosal immunity and protects against H5N1 and H7N9 influenzaAbstractSeasonal and pandemic influenza viruses are continuous threats to human health, requirin...
Neutrophils as critical orchestrators of chronic inflammationAbstractNeutrophils are the first key effector innate immune cells recruited toward inflammatory sites. Through the release of neutrophi...
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairmen
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVIDAbstractThe mechanisms driving immune dysregulation in long COVID disease remain e...
Lineage tracing reveals the origins and dynamics of macrophages in lung injury and repairAbstractMacrophages play a vital role in tissue repair and regeneration following injury. However, the cell ...
Gut dysbiosis in oncology: a risk factor for immunoresistanceAbstractThe gut microbiome is recognized as a determinant of response to immune checkpoint inhibitor (ICI) therapies in cancer. However,...
6-Phosphogluconate dehydrogenase promotes mitochondrial fusion and immune suppression in tumor-assoc
6-Phosphogluconate dehydrogenase promotes mitochondrial fusion and immune suppression in tumor-associated monocytic suppressor cellsAbstractThe mechanisms underlying the metabolic adaptation of mye...
TRIP13 promotes the expansion and immunosuppression of CD4+Foxp3+ regulatory T cells by sustaining H
TRIP13 promotes the expansion and immunosuppression of CD4+Foxp3+ regulatory T cells by sustaining HAT1 stabilityAbstractThere is compelling evidence that TNF preferentially activates and expands C...
The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunctionAbstractThe multifaceted dysfunction of tumour-infiltrating T cells, including exhaustion and mitochondrial dysfunction, remai...
Disease tolerance and infection pathogenesis age-related tradeoffs in miceAbstractDisease tolerance is a defence strategy essential for survival of infections, limiting physiological damage without...
Microbiota-induced T cell plasticity enables immune-mediated tumour controlAbstractTherapies that harness the immune system to target and eliminate tumour cells have revolutionized cancer care. Imm...
Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function
Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial functionAbstractLipophagy is a form of selective autophagy that targets the lipid droplets for lysosomal ...
Microgravity and cancer cells: from molecular mechanisms to therapeutic strategiesAbstractAll living organisms on Earth have evolved mechanisms to counteract the effects of gravity. In space, howev...
Dual roles of circadian clock proteins in development and adult homeostasisAbstractCircadian clocks coordinate physiology with daily cycles. Loss of circadian components disrupts bodily functions, ...
Tryptophan metabolic gatekeeping in epithelial repair: GPR35-KLF5 circuitry decodes mucosal damage s
Tryptophan metabolic gatekeeping in epithelial repair: GPR35-KLF5 circuitry decodes mucosal damage signals for repair programmingAbstractThe impaired repair of intestinal mucosal damage is an impor...
VIRMA/IGF2BP3-mediated ANLN upregulation promotes intrahepatic cholangiocarcinoma growth by forming a positive feedback loop with RhoA/YAP1/TEAD1 signaling pathwayAbstractThe prognosis of patients ...
O-GlcNAcylation of XRCC4 controls its stability and confers resistance to DNA double-strand break da
O-GlcNAcylation of XRCC4 controls its stability and confers resistance to DNA double-strand break damage in cancer cellsAbstractX-ray repair cross-complementing protein 4 (XRCC4), a non-homologous ...
RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stressAbstractSLFN11 is epigenetically silenced and confers chemoresistance in half of all cancers. In response to rep...
MSLN-mediated activation of EGFR-ERK1/2 signaling drives liver metastasis in breast cancerAbstractBreast cancer (BC) is the most prevalent malignant disease affecting female patients globally, with...
FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced
FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulationAbstractCholestatic liver injury, characterized by direct exposure of hepatoc...
Identification of ACBP as a potential target in ciliopathic obesity through multi-omics network anal
Identification of ACBP as a potential target in ciliopathic obesity through multi-omics network analysisAbstractCiliopathies are genetic disorders characterized by defective primary cilia function,...
Cancer cachexia: molecular basis and therapeutic advancesAbstractThe dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesi...
Evaluating progesterone receptor agonist megestrol plus letrozole for women with early-stage estroge
Evaluating progesterone receptor agonist megestrol plus letrozole for women with early-stage estrogen-receptor-positive breast cancer: the window-of-opportunity, randomized, phase 2b, PIONEER trial...
De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T ce
De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell functionAbstractDiffuse midline glioma (DMG) is a highly aggressive and untreatable pediatric ...
TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant meta
TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasisAbstractDifferent forms of epithelial-to-mesenchymal transition (EMT) manifest during tumor...
Axicabtagene ciloleucel in combination with rituximab for refractory large B cell lymphoma: the phas
Axicabtagene ciloleucel in combination with rituximab for refractory large B cell lymphoma: the phase 2, single-arm ZUMA-14 trialAbstractCD19-negative relapse occurs in ~30% of persons with relapse...
CAR-adapted PIK3CD base editing enhances T cell anti-tumor potencyAbstractInsufficient functional T cell persistence impedes therapeutic success of chimeric antigen receptor (CAR) therapies. Here w...
Real-world clinical utility of comprehensive genomic profiling in advanced solid tumorsAbstractComprehensive genomic profiling (CGP) is crucial in precision oncology, yet its real-world utility rem...
Immuno-acoustic trapping for extracellular vesicle subpopulationsAbstractExtracellular vesicles (EVs) in biofluids are heterogeneous in origin, surface protein expression, and biomolecular cargo. I...
Sepsis-induced coagulopathy: recent insights on the role and clinical application of neutrophil extr
Sepsis-induced coagulopathy: recent insights on the role and clinical application of neutrophil extracellular trap formationAbstractSepsis is characterized by life-threatening organ dysfunction cau...
Revitalizing T cells: breakthroughs and challenges in overcoming T cell exhaustionAbstractT cell exhaustion is a prevalent phenomenon in chronic infections and tumor microenvironments, severely com...
Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to
Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to jointsAbstractPsoriatic disease initially affects the skin and later extends to the joints. Here...
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling recept
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptorsAbstractAdoptive T cell therapy using T cells engineered with novel T cell receptors (TCRs) ta...
Acute exercise rewires the proteomic landscape of human immune cellsAbstractThe positive effect of exercise on the immune system is widely acknowledged, but the molecular response of immune cells t...
Utility of plasma MicroRNA profiling as diagnostic biomarker in immune system activation and inflamm
Utility of plasma MicroRNA profiling as diagnostic biomarker in immune system activation and inflammation and early predictor of severity in patients with COVID-19AbstractThe clinical course of Cor...
Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatoc
Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinomaAbstractT-cell engager (TCE)-based immunotherapy is clinically validated in hema...
Cancer stage at diagnosis by duration of pre-existing chronic analgesic use and anxiety or depressio
Cancer stage at diagnosis by duration of pre-existing chronic analgesic use and anxiety or depressionAbstractPre-existing chronic diseases may delay or expedite cancer diagnosis. Here, we examine v...
Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerab
Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastomaAbstractMYC-driven medulloblastoma (MB) is a highly aggressive...
Dynamic release of extracellular particles after opening of the blood-brain barrier predicts gliobla
Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxelAbstractLiquid biopsies hold promise to improve the diagnosis, ...
Highly conserved Plasmodium vivax genomes in Duffy-negative individuals from SudanAbstractDuffy-negatives were previously thought to be immune to Plasmodium vivax infections due to Duffy binding pr...
IgE-mediated sensitizations to Blomia tropicalis allergens in Malaysian allergic populationAbstractAllergic sensitizations to Dermatophagoides pteronyssinus and Dermatophagoides farinae house dust ...
Bigger is faster in the adaptive immune responseAbstractZoonotic pathogens represent a growing global risk, yet the speed of adaptive immune activation across mammalian species remains poorly under...
Carnosol exerts anti-inflammatory effects in pulpitis by inhibiting the RAGE/NF-κB signalling pathwa
Carnosol exerts anti-inflammatory effects in pulpitis by inhibiting the RAGE/NF-κB signalling pathwayAbstractEffective pulpal inflammation control remains a global challenge. This study evaluated t...
Integrative in vitro and in silico evaluation of HSP60-derived peptides as immunomodulators of the T
Integrative in vitro and in silico evaluation of HSP60-derived peptides as immunomodulators of the TLR4/MD-2 complexAbstractThis study investigated the activity of HSP60-derived peptides on the hum...
Deciphering the clinical implication of an obesity-related gene signature as the novel biomarker for
Deciphering the clinical implication of an obesity-related gene signature as the novel biomarker for acute myocardial infarction diagnosisAbstractAcute myocardial infarction (AMI) stands as a major...
Pilot study on exercise-induced placental transcriptomic changes and oxidative stress reduction in g
Pilot study on exercise-induced placental transcriptomic changes and oxidative stress reduction in gestational diabetes mellitusAbstractGestational diabetes mellitus (GDM) is a common pregnancy com...
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumorsAbstractCD8+ T cells are an important weapon in the therapeutic armamentarium against cancer. While CD8+CD103+ T cel...
No naturally occurring blood group antibodies were detected in the crossmatching of 25 giant pandasAbstractThe giant panda (Ailuropoda melanoleuca) is a vulnerable species of ursid, endemic to Chin...
Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lympho
Novel anti-ITGA4 monoclonal antibody induces cell death via large pore formation in NK/T-cell lymphoma cellsAbstractNatural killer (NK)/T-cell lymphomas are a highly aggressive lymphoma subtype com...
Discovery of potent cross-neutralizing antibodies against Marburg and Ravn viruses with therapeutic potentialAbstractMarburg virus (MARV) and Ravn virus (RAVV) are highly pathogenic filoviruses tha...
Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochond
Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppressionAbstractColorectal cancer (CRC) is a prevalent malignant tum...
IFN-γ and IL-4 correlate with protection induced by an attenuated malaria vaccineAbstractControlled human malaria infections after immunization via mosquito bites with radiation attenuated Plasmodi...
Critical role of the CMGC insert sequence for tyrosine autophosphorylation in the protein kinase DYR
Critical role of the CMGC insert sequence for tyrosine autophosphorylation in the protein kinase DYRK1BAbstractMany CMGC group kinases require phosphorylation of a conserved tyrosine residue in the...
Trichosanthes kirilowii Maximowicz attenuates dexamethasone induced atrophy in C2C12 myotubes throug
Trichosanthes kirilowii Maximowicz attenuates dexamethasone induced atrophy in C2C12 myotubes through a Sirtuin 1 associated mechanismAbstractGlucocorticoids such as dexamethasone (DEX) are commonl...
Proteomics analysis reveals progesterone receptor induced mitochondria-mediated apoptosis in breast cancer cellsAbstractThe progesterone receptor (PR) expression is associated with disease-free sur...
Generation and ophthalmological characterization of oculocutaneous albinism type 1 pig models by sel
Generation and ophthalmological characterization of oculocutaneous albinism type 1 pig models by selection-free genome editingAbstractOculocutaneous albinism type 1 (OCA1) is an autosomal recessive...
A novel accessible in vitro model of proliferative vitreoretinal diseases shows facilitated epitheli
A novel accessible in vitro model of proliferative vitreoretinal diseases shows facilitated epithelial mesenchymal transition through aquaporin-1AbstractThis study aimed to establish a new in vitro...
Impact of particle size and surface modifications on the neurotoxic potential of copper oxide nanopa
Impact of particle size and surface modifications on the neurotoxic potential of copper oxide nanoparticlesAbstractCopper oxide (CuO) nanoparticles (NPs) have widespread applications in electronics...
Platelet-rich plasma-derived exosomes establishing a muscular proregenerative microenvironment throu
Platelet-rich plasma-derived exosomes establishing a muscular proregenerative microenvironment through enhancing the viability of fibro-adipogenic progenitorsAbstractClinical studies have shown a p...
Multi-scale classification decodes the complexity of the human E3 ligomeAbstractE3 ubiquitin ligases are vital enzymes that define the ubiquitin code in cells. Beyond promoting protein degradation ...
C/EBPβ-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblas
C/EBPβ-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastomaAbstractGlioblastoma (GBM) is an aggressive brain tumor with limited treatment options and a ...
The moderating role of diet and physical activity in insulin resistance and immunometabolic depressi
The moderating role of diet and physical activity in insulin resistance and immunometabolic depressionAbstractInsulin resistance (IR) and atypical depression share an immunometabolic pathway and pr...
SARS-CoV-2-specific B cell responses in non-draining lymph nodes and antibody functionalities in imm
SARS-CoV-2-specific B cell responses in non-draining lymph nodes and antibody functionalities in immunized end-stage renal disease patientsAbstractThe degree to which COVID-19 vaccination induces B...
Melatonin attenuates glandular cystitis via modulation of THBS1 and TLR4/p38 MAPK/STAT3 signalingAbstractMelatonin (MEL) is a natural hormone widely found in animals and humans. A multitude of stud...
Pre-activation timing determines influenza severity and viral pathogenicity via STING InhibitionAbstractSevere influenza is frequently associated with bacterial or viral co-infections. Although imm...
Recruitment of CCR5+ inflammatory monocytes in pulmonary tissue contributes to acute lung injuryAbstractAcute lung injury (ALI) is a common serious complication following deep hypothermic circulato...
Working together: a multi-component intranasal vaccine provides synergistic protection against COVID
Working together: a multi-component intranasal vaccine provides synergistic protection against COVID-19In their recent publication in Nature Biomedical Engineering, Hong and colleagues1 report on t...
Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflamma
Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel diseaseAbstractCurrent therapies for inflammatory bowel disease (IBD) often fail to ac...
Molecular assessment of the HIV pol gene and use of computational vaccine design targeting Pakistani
Molecular assessment of the HIV pol gene and use of computational vaccine design targeting Pakistani isolatesAbstractHuman immunodeficiency virus (HIV) is considered a major threat to human health....
Bioinformatic analysis of glycosylation-related genes in intervertebral disc degeneration and their roles in immune infiltration and diagnostic modelsAbstractIntervertebral disc degeneration (IDD) ...
The resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complexAbstractThe T-cell receptor (TCR) initiates T-lymphocyte activation, but the mechanism of TCR activatio...
MAT2A promotes atherosclerotic plaque vulnerability by mediating epigenetic reprogramming of macroph
MAT2A promotes atherosclerotic plaque vulnerability by mediating epigenetic reprogramming of macrophagesAbstractAtherosclerosis is mediated by circulating monocytes and lesional macrophages through...
Hemolysis-induced hepatic ferroptosis following xenotransfusion of genetically modified pig red bloo
Hemolysis-induced hepatic ferroptosis following xenotransfusion of genetically modified pig red blood cellsAbstractTo overcome cross-species immunological barriers, researchers utilize gene editing...
The chaperone GRP94 interacts with the proprotein convertase furin and regulates TGF-beta maturation
The chaperone GRP94 interacts with the proprotein convertase furin and regulates TGF-beta maturation in human primary M2 macrophagesAbstractTransforming growth factor-beta (TGFβ) is a major immunos...
GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility du
GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during agingAbstractAging is characterized by amplified inflammation, including proinflammatory mac...
mRNA vaccines encoding variant forms of Sm-TSP-2 confer protective immunity against Schistosoma mans
mRNA vaccines encoding variant forms of Sm-TSP-2 confer protective immunity against Schistosoma mansoniAbstractThis study explored the development and evaluation of mRNA vaccine candidates targetin...
Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-relat
Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctionsAbstractCellular senescence is deeply involved in physiological homeostasis, devel...
Anti-neuraminidase and anti-HA stalk antibodies reduce the susceptibility to and infectivity of infl
Anti-neuraminidase and anti-HA stalk antibodies reduce the susceptibility to and infectivity of influenza A/H3N2 virusAbstractImmune responses against neuraminidase (NA) and hemagglutinin (HA) are ...
Inflammatory mediators differentially regulate megakaryopoiesis and thrombopoiesis in myelofibrosis and essential thrombocythemiaAbstractChronic myeloproliferative neoplasms are characterized by cl...
A T-cell receptor targeting RUNX1 frameshift mutations in acute myeloid leukemiaAbstractRunt-related transcription factor 1 (RUNX1) is a key regulator of hematopoietic differentiation. RUNX1 mutati...
Organoid: a promising solution to current challenges in cancer immunotherapyAbstractCancer immunotherapies, including immune checkpoint blockade and engineered T cell therapies, have revolutionized...
Target cell cortical tension regulates macrophage trogocytosisAbstractMacrophages are known to engulf small membrane fragments, or trogocytose, target cells and pathogens, rather than fully phagocy...
Long COVID involves activation of proinflammatory and immune exhaustion pathwaysAbstractLong COVID (LC) involves a spectrum of chronic symptoms after acute severe acute respiratory syndrome coronav...
Interferon-stimulated gene GALNT2 restricts respiratory virus infectionsAbstractThe innate immune response involves interferons (IFNs), antiviral cytokines that upregulate numerous IFN-stimulated g...
Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites i
Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cellsAbstractThe development of e...
Streptococcus gordonii type VII secretion system substrate EsxA induces neutrophil extracellular tra
Streptococcus gordonii type VII secretion system substrate EsxA induces neutrophil extracellular trap formation in infective endocarditisAbstractType VII secretion system (T7SS) substrate EsxA cont...
Search-and-remove genome editing allows selection of cells by DNA sequenceAbstractThe selection of cells that have acquired a desired gene edit is often done by the introduction of additional genes...
Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutationsAbstractVariants of uncertain significance represent the biggest challenge for genomics-based precis...
Precise diagnosis of small invasive pulmonary nodules driven by single-cell immune signatures in per
Precise diagnosis of small invasive pulmonary nodules driven by single-cell immune signatures in peripheral bloodAbstractEarly detection of lung cancer is crucial for improving patient outcomes. Ho...
Clonal cell states link gastroesophageal junction tissues with metaplasia and cancerAbstractBarrett’s esophagus is a common type of metaplasia and a precursor of esophageal adenocarcinoma. However,...
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy re
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responsesAbstractReducing calorie intake through dietary restriction (DR) slows tumour growth in ma...
Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance
Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumorsAbstractThe immunosuppressive tumour microenvironment (TME) re...
ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung c
ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancerAbstractSmall cell lung cancer (SCLC) is characterized by its highly aggressive phenotype an...
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy re
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responsesAbstractReducing calorie intake through dietary restriction (DR) slows tumour growth in ma...
Photo-reversible amyloid nanoNETs for regenerative antimicrobial therapiesAbstractDrug-resistant bacterial infections, exacerbated by antibiotic resistance and biofilm resilience, disrupt tissue re...
Human gut M cells resemble dendritic cells and present gluten antigenAbstractMicrofold (M) cells are rare intestinal epithelial cells that reside in the follicle-associated epithelium of Peyer’s pa...
BNIP3 is a key driver of breast cancer progression and a novel glycolysis-regulating biomarkerAbstractBreast cancer (BC) represents a leading cause of cancer-related mortality among women, with gly...
Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the C
Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemicAbstractThe rebound of endemic respiratory viruses following the COVID-19 pandemi...
89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment wit
89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4AbstractAnti-CD8 immunoPET facilitates non-invasive, whole-body visuali...
Light-emitting diode red light attenuates epidermal thickening and keratinocyte proliferation in pso
Light-emitting diode red light attenuates epidermal thickening and keratinocyte proliferation in psoriasis modelsAbstractPsoriasis is an immune-mediated skin condition that impacts approximately 3%...
Key regulatory roles of PRDM1 in human NK-cell differentiation and activationAbstractPRDM1, encoding a transcription factor (TF), regulates plasma cell and CD8+ T-cell terminal differentiation and ...
Multi-omics profiling identifies ESM1 as a key mediator of immunoevasion through the SPP1 pathway in
Multi-omics profiling identifies ESM1 as a key mediator of immunoevasion through the SPP1 pathway in bladder cancerAbstractTo investigate the predictive value of Endothelial cell-specific molecule ...
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy re
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responsesAbstractReducing calorie intake through dietary restriction (DR) slows tumour growth in ma...
COVID-19 pandemic and waning immunity disrupted measles population immunity and strategies to close immunity gapsAbstractWidespread measles cases following the COVID-19 pandemic have threatened hum...
Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransductionAbstractCytosolic phospholipase A2 (cPLA2) controls some of the most powerful inflammatory lipids in vertebrates by r...
Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilizationAbstractCellular stress response pathways are essential for genome stability and are frequently dysregulate...
Mammo-AGE: deep learning estimation of breast age from mammogramsAbstractBiological age is an important indicator of organ functions and health. Although mammograms are widely used in breast cancer...
Targeting CDK9-dependent transcriptional addiction: a novel chemoprevention strategy for oral carcin
Targeting CDK9-dependent transcriptional addiction: a novel chemoprevention strategy for oral carcinogenesis via adenosine deaminase modulationAbstractOncogenic dysregulation of transcription can e...
Predictive models of melanoma metastasis based on dermatoscopy in an international retrospective hum
Predictive models of melanoma metastasis based on dermatoscopy in an international retrospective human reader studyAbstractCurrent melanoma prognostic tools have limited clinical use at the bedside...
Lysophosphatidylethanolamine 18:1 drives clear cell renal cell carcinoma by stabilizing SIRT6 to rep
Lysophosphatidylethanolamine 18:1 drives clear cell renal cell carcinoma by stabilizing SIRT6 to reprogram lipid metabolismAbstractClear cell renal cell carcinoma (ccRCC) is characterized by profou...
Inflammatory transcriptomic signatures in a human cellular NMOSD model reveal upregulation of NF-κB and IL6 pathwaysAbstractNeuromyelitis optica spectrum disorder (NMOSD) is a rare neurological aut...
Pubertal stage specific changes in T-cell subpopulations in healthy individualsAbstractThis study investigates how puberty affects T-cell subpopulations in healthy individuals, aiming to understand...
Ferritinophagy-related prognostic genes UBE2Q1, NEDD4L, and TCP11L2 for prognosis prediction in seps
Ferritinophagy-related prognostic genes UBE2Q1, NEDD4L, and TCP11L2 for prognosis prediction in sepsisAbstractSepsis remains a critical global health threat characterized by high mortality and comp...
Real-world analysis of immune checkpoint inhibitor efficacy and response predictors in patients trea
Real-world analysis of immune checkpoint inhibitor efficacy and response predictors in patients treated at the CCCMunichLMU outpatient clinicAbstractPrediction of response to checkpoint inhibition ...
Dracorhodin perchlorate alleviates sciatic nerve pain in CCI rats by modulating inflammation and pro
Dracorhodin perchlorate alleviates sciatic nerve pain in CCI rats by modulating inflammation and promoting nerve repairAbstractThis study analyzed protein sequencing from rat samples, categorized i...
Pre-existing cross-reactive immunity to highly pathogenic avian influenza 2.3.4.4b A(H5N1) virus in the United StatesAbstractThe unprecedented 2.3.4.4b. A(H5N1) outbreak in dairy cattle, poultry, a...
Whole mastic resin ameliorates halitosis and gingivitis in dogs and cats infected with Porphyromonas
Whole mastic resin ameliorates halitosis and gingivitis in dogs and cats infected with Porphyromonas gulaeAbstractMastic, a natural resin, has long been used to prevent periodontal disease, but mos...
People with cystic fibrosis with high sputum neutrophil elastase on elexacaftor-tezacaftor-ivacaftor
People with cystic fibrosis with high sputum neutrophil elastase on elexacaftor-tezacaftor-ivacaftor exhibit worse pulmonary function and pro-inflammatory airway milieuAbstractCystic fibrosis (CF) ...
NIR-IIb fluorescence ratiometric imaging of tumor-associated neutrophils for immunotherapy efficacy monitoring and strategy optimizationAbstractImaging the immune activation status of tumor-associa...
Cross-herpesvirus immunity of the cytomegalovirus gB/MF59 vaccine responseAbstractVaccination against human cytomegalovirus (HCMV) to protect transplant recipients and prevent congenital infection ...
Influenza A(H5N8) vaccine induces humoral and cell-mediated immunity against highly pathogenic avian
Influenza A(H5N8) vaccine induces humoral and cell-mediated immunity against highly pathogenic avian influenza clade 2.3.4.4b A(H5N1) viruses in at-risk individualsAbstractFinland faced an outbreak...
Immunologic and biophysical features of the BNT162b2 JN.1 and KP.2 adapted COVID-19 vaccinesAbstractThe rise in prevalence of the SARS-CoV-2 JN.1 lineage in 2023 and subsequent derivative sublineag...
Single cell mapping identifies a distinct platelet-phenotype in psoriatic type III inflammationAbstractThe understanding of platelet biology is expanding beyond their well-established role in throm...
Fatty acid-binding protein 5 aggravates psoriasis and psoriasis-like disease through ferroptosisAbstractPsoriasis (Ps) is a chronic inflammatory skin disease with systemic manifestations, such as p...
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptorsAbstractSensing of viral pathogens by RIG-I-like receptors (RLRs) requires their priming via dephosphorylation mediated by the p...
IL-1 receptor antagonist as a diagnostic biomarker for bacterial infections in acute decompensation of cirrhosisAbstractLiver cirrhosis is a chronically progressive disease often leading to severe ...
Neutrophil extracellular traps in cancer: immune modulation, therapy resistance, and the dilemma of targetingAbstractThe release of extracellular DNA is a highly conserved mechanism across species....
B lymphocytes contribute Angiotensin II induced cardiac hypertrophyAbstractImmune responses play a critical role in myocardial injury, yet the specific contribution of B lymphocyte-dependent mechan...
The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cellsAbstractDuring cancer immunoediting, cancer cells deregulate cell death executioner mechanisms to escape immunoth...
The fibroblast epigenome underlies SS18::SSX-mediated transformation in synovial sarcomaAbstractSynovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomon...
Physiological activation of Aryl hydrocarbon receptor by food-derived ligands is essential for the e
Physiological activation of Aryl hydrocarbon receptor by food-derived ligands is essential for the efficacy of anti-PD1 therapyAbstractCancer immuno-surveillance and response to therapy are affecte...
AbstractMyeloid cell leukemia-1 (MCL1) is among the most overexpressed proteins in tumors. MCL1 contributes to tumorigenesis by antagonizing apoptosis. However, apoptosis-unrelated functions are em...
IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pa
IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancerAbstractAlthough ubiquitin-conjugating enzymes are critical regulators of cellular...
The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal m
The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membraneAbstractMost Epstein–Barr virus-associated gastric carcinoma (EBVaGC) harbor non-silent mu...
Targeting of HIF2-driven cachexia in kidney cancerAbstractKidney cancer frequently causes paraneoplastic syndromes, including hypercalcemia and cachexia, but the underlying mechanisms are incomplet...
Photobiomodulation stimulates mitochondrial function and cell proliferation in meniscus-derived stem
Photobiomodulation stimulates mitochondrial function and cell proliferation in meniscus-derived stem cells (MeSCs) via activation of TRPV1 channelAbstractThe meniscus is a crescent-shaped knee stru...
In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammationAbstractHere we established an in vivo CRISPR screening pipeline using genetically editable progenitor cells to dis...
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and mem
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formationAbstractT cell activation requires extensive metabolic reprogramming, but the specif...
LIMD2 is associated with an exhausted CD8⁺ T cell state linked to ICI response in clear cell renal c
LIMD2 is associated with an exhausted CD8⁺ T cell state linked to ICI response in clear cell renal cell carcinomaAbstractClear cell renal cell carcinoma (ccRCC) is characterized by abundant infiltr...
Autoantibody landscape and functional role of anti-C-C motif chemokine receptor 8 autoantibodies in systemic sclerosis: post-hoc analysis of a B-cell depletion trialAbstractSystemic sclerosis (SSc)...
Prophylactic infusion of donor derived CMV specific T cells for the prevention of CMV reactivation f
Prophylactic infusion of donor derived CMV specific T cells for the prevention of CMV reactivation following allogeneic HSCTAbstractCytomegalovirus (CMV) reactivation remains a common and serious c...
A comprehensive analysis of transfusion trends and patient outcomes in blood utilization practices a
A comprehensive analysis of transfusion trends and patient outcomes in blood utilization practices at Jimma university medical centerAbstractIn resource-limited settings like Ethiopia, ensuring ade...
Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulinAbstractChronic inflammation in adipose tissue is widely recognized as a pivotal link connecting obesity to a spe...
APIP regulates the priming of canonical NLRP3 and non-canonical Caspase-11/4 inflammasomes by bindin
APIP regulates the priming of canonical NLRP3 and non-canonical Caspase-11/4 inflammasomes by binding to TRAF6AbstractApaf-1-interacting protein (APIP) has been implicated in inflammation-related p...
Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structu
Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancerAbstractTertiary lymphoid structures (TLSs) have emerged as critical prognos...
Apatinib plus ifosfamide and etoposide versus ifosfamide and etoposide in patients with advanced ost
Apatinib plus ifosfamide and etoposide versus ifosfamide and etoposide in patients with advanced osteosarcomas (OAIE/PKUPH-sarcoma 11): a randomized phase II studyAbstractRelapsed or refractory ost...
Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidenceAbstractTherapeutic options for patients with renal medullary ca...
A therapeutic peptide vaccine for fibrolamellar hepatocellular carcinoma: a phase 1 trialAbstractFibrolamellar hepatocellular carcinoma (FLC) is a rare form of liver cancer affecting children and y...
Comparative transcriptome atlas as an assistive modality for complex classification of rare kidney c
Comparative transcriptome atlas as an assistive modality for complex classification of rare kidney cancersAbstractThere is a great unmet medical need for development of molecularly characterizing m...
Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processin
Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulationsAbstractExpansion of RNA polymerase III (Pol III) activity in cancer can ...
Immune cells dying from ferroptosis: mechanisms and therapeutic opportunitiesAbstractThis review explores the intricate regulation of ferroptosis through diverse pathways and related metabolism, fo...
Prognostic and immunological potential of AC012236.1/hsa-miR-30d-5p CeRNA of AVEN by integrated anal
Prognostic and immunological potential of AC012236.1/hsa-miR-30d-5p CeRNA of AVEN by integrated analysis of single-cell and bulk RNA-seq in lung adenocarcinomaAbstractLung adenocarcinoma (LUAD) is ...
Transcriptomic exploration of key genes related to mitochondria and ferroptosis in inflammatory bowe
Transcriptomic exploration of key genes related to mitochondria and ferroptosis in inflammatory bowel disease and experimental validationAbstractInflammatory bowel disease (IBD) is a systemic condi...
Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunoth
Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapyAbstractAcute myeloid leukemia (AML) is primarily driven by leukemic stem cells (LSCs), the ...
Immunological risk factors for recurrent implantation failure using a deep learning model: a multice
Immunological risk factors for recurrent implantation failure using a deep learning model: a multicenter retrospective cohort studyAbstractDespite advancements in assisted reproductive technology (...
Low neutrophil-to-lymphocyte ratio identifies secondary polycythemia in patients with erythrocytosis
Low neutrophil-to-lymphocyte ratio identifies secondary polycythemia in patients with erythrocytosisAbstractThe neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammation, may a...
GPR43 in eosinophils suppresses the emergence of pathogenic Siglec-Fhi neutrophils in allergic airwa
GPR43 in eosinophils suppresses the emergence of pathogenic Siglec-Fhi neutrophils in allergic airway inflammation in miceAbstractEosinophils are major effector cells in type 2 immune responses, co...
Multimodal AI and tumour microenvironment integration predicts metastasis in cutaneous melanomaAbstractAccurate prognostication is essential to guide clinical management in localised cutaneous mela...
AbstractDIS3 licenses B cells for plasma cell differentiation in humansDIS3 is the main catalytic subunit of the nuclear RNA exosome, a complex playing a crucial role in RNA processing and the degr...
Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular c
Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal agesAbstractDysregulated metabolism in tumor tissues and para-tumor ti...
The sex-biased chromatin modifier SMC1A promotes autoimmunity by shaping inflammatory pathways in pa
The sex-biased chromatin modifier SMC1A promotes autoimmunity by shaping inflammatory pathways in patients with SLEAbstractA strong female bias is characteristic of systemic lupus erythematosus (SL...
PER3 suppresses lung adenocarcinomatous cell proliferation/migration through activating AMPK/mTOR pa
PER3 suppresses lung adenocarcinomatous cell proliferation/migration through activating AMPK/mTOR pathwayAbstractDysregulation of circadian rhythm genes is related to the increased risk of developm...
TSCM-predominant allogeneic anti-BCMA CAR-T therapy for relapsed/refractory multiple myeloma: precli
TSCM-predominant allogeneic anti-BCMA CAR-T therapy for relapsed/refractory multiple myeloma: preclinical characterization and interim results from a phase 1 trialAbstractAutologous CAR-T therapies...
Practical considerations for clinical translation of PET imaging of adoptive cell therapiesAbstractResearch and development programs for adoptive cell therapies continue to expand, but few products...
Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signal
AbstractThe PD-L1 immune checkpoint ligates the PD-1 immune checkpoint, and antibodies against either are effective in treating selected human cancers. Although PD-L2 also ligates PD-1, αPD-L2 is l...
Migration of CD8 + TSCM cells into intestine via PPBP–CXCR2 axis increases host stress susceptibilit
AbstractPsychosocial stress impacts immune system and brain function, yet mechanisms linking peripheral immune dysregulation to major depressive disorder remain unclear. Here, we demonstrate that a...
Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-Fc
AbstractOveractivation of FcγRI by immune complexes (IC) is implicated in various autoimmune disorders and neuropathies. Currently, no effective FcγRI-specific blocking antibodies are available. He...
Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mil
AbstractRepeated mild closed head injury (rmCHI) is a significant public health concern, and this type of repetitive injury is garnering increasing attention, not least because of its increasing in...
ImmunoMatch learns and predicts cognate pairing of heavy and light immunoglobulin chainsAbstractThe development of stable antibodies formed by compatible heavy (H) and light (L) chain pairs is cruc...
HHQG ameliorates acute liver injury (ALI) by inhibiting NLRP3 activation through RASD1-mediated regu
HHQG ameliorates acute liver injury (ALI) by inhibiting NLRP3 activation through RASD1-mediated regulation of the PKCδ-NF-κB signaling pathwayAbstractAcute liver injury (ALI) is a prevalent hepatic...
Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cellsAbstractImproved ex vivo expansion of human haematopoietic stem cells (HSCs) would considerably advance transplan...
Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immuni
Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in miceAbstractPrecise regulation of type I interferon signaling is crucial for effective immu...
Gli1-expressing stromal cells are highly reparative precursors of long-lived chondroprogenitors in t
Gli1-expressing stromal cells are highly reparative precursors of long-lived chondroprogenitors in the fetal murine limbAbstractThe growth-plate cartilage of the developing long bones is a well-kno...
MAFB regulates hematopoietic stem cell proliferation and maintenanceAbstractMAFB, a transcription factor of the large Maf family, is expressed in both fetal liver (FL) and bone marrow (BM) hematopo...
TBC1D1 functions as a negative regulator of satellite cells for muscle regenerationAbstractThe Rab GTPase activating protein (RabGAP) AS160 translocates from the cytosol into the nucleus acting as ...
Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasiaAbstractSomatic mutations in hematopoietic stem/progenitor cells (HSPCs) can le...
Olig1/2 Orchestrates Progenitor Cell Fates during Mammalian Cortical Gliogenesis and GliomagenesisAbstractDuring cortical gliogenesis, tri-potential intermediate progenitor cells (Tri-IPCs) differe...
PRKG1 hinders myogenic differentiation and predicts response to AKT inhibitor ipatasertib in Rhabdom
PRKG1 hinders myogenic differentiation and predicts response to AKT inhibitor ipatasertib in RhabdomyosarcomaAbstractRhabdomyosarcoma (RMS) is marked by a myogenesis differentiation blockade, and w...
Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vul
Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic VulnerabilitiesAbstractRNA splicing dysregulation has emerged as a hallmark of cancer and a promisin...
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinomaAbstractHuman isotopic tracer studies are key for in vivo studies of cancer metabolism. Yet, the effects...
A monoclonal antibody that inhibits the shedding of CD16a and CD16b and promotes antibody-dependent cellular cytotoxicity against tumorsAbstractCD16a triggers antibody-dependent cellular cytotoxici...
Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunothe
Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinomaAbstractIncreasing evidence indicates that activation of oncogeni...
Engineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against dif
Engineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against diffuse intrinsic pontine gliomaAbstractDiffuse intrinsic pontine glioma (DIPG) is a fatal brainstem...
Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depend
Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 statusAbstractThe resistance to KRAS-targeted therapies, particularly due to co-occu...
FOXO1-driven metabolic reprogramming of hematomal CD8+ T cells drives the expansion of perihematomal
FOXO1-driven metabolic reprogramming of hematomal CD8+ T cells drives the expansion of perihematomal edema following intracerebral hemorrhageAbstractIntracerebral hemorrhage (ICH) causes hematoma f...
Apheresis platelets modulate myeloid dendritic cell immune responsesAbstractPlatelet transfusion is important in clinical treatment, especially for patients with hematological diseases. In this stu...
The dual impact of oxidative stress on breast cancerAbstractThe impact of oxidative stress on breast cancer remains unknown, and further research is urgently needed. Datasets from TCGA, METABRIC, a...
Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessme
Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessmentAbstractThe immune imprinting against SARS-CoV-2 subvariants that dynamically evolves through s...
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction w
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptorsAbstractAmyloid proteins are linked to various diseases; however, their f...
Heme processing in the malaria parasite, Plasmodium falciparum: a time-dependent basal-level analysi
Heme processing in the malaria parasite, Plasmodium falciparum: a time-dependent basal-level analysisAbstractMalaria is a deadly disease for which therapeutic options are threatened by the rise of ...
qMaLioffG: a genetically encoded green fluorescence lifetime-based indicator enabling quantitative i
qMaLioffG: a genetically encoded green fluorescence lifetime-based indicator enabling quantitative imaging of intracellular ATPAbstractGenetically encoded indicators that can detect concentrations ...
Irradiated obese adipocytes are prone to oxidative stress, inflammation, senescence, and fibrosisAbstractCancer patients with obesity who undergo radiotherapy are more likely to suffer from side ef...
Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneo
Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneous insulin receptor endocytosisAbstractDysregulation of heat shock protein DNAJA2 induces genomic...
Near telomere to telomere genome assembly of Chinese yellow rabbit (Oryctolagus cuniculus)AbstractOryctolagus cuniculus (Fujian Yellow Rabbit; FJY), the only indigenous rabbit breed in China, known...
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1AbstractTumor necrosis factor (TNF)-induced RIPK1-mediated cell death is implicated in various huma...
Mixed granulocytic airway inflammation impairs aversive learning and alters neuroimmune biomarkers i
Mixed granulocytic airway inflammation impairs aversive learning and alters neuroimmune biomarkers in miceAbstractAsthma is characterized by different phenotypes of airway inflammation, granulocyti...
Comparison of basophil activation testing and component-resolved diagnosis in patients with cross-re
Comparison of basophil activation testing and component-resolved diagnosis in patients with cross-reactive intradermal results after anaphylactic reactions to hymenoptera venomAbstractHymenoptera v...
Dual effects of the alternative spliced RIG-I isoform PTIR1 on host antiviral defense and immune hom
Dual effects of the alternative spliced RIG-I isoform PTIR1 on host antiviral defense and immune homeostasisAbstractEfficient pathogen recognition must be tightly regulated to prevent immunopatholo...
Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervent
Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic interventionAbstractHuman T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) is a debilitat...
LUBAC modulates CBM complex functions downstream of TRAF6 in T cellsAbstractThe CARD11-BCL10-MALT1 (CBM) complex drives NF-κB signaling and MALT1 protease activation after T cell receptor (TCR) sti...
Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsisAbstractSepsis-induced liver injury is common, but the underlying mechanisms remain poorly understood. Given t...
CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional dow
CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagyAbstractVascular smooth muscle cells (VSMCs) are a significant source of ...
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome indu
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegansAbstractTranscription factors DAF-16/FOXO and HLH-30/TFEB have been linked to ...
HMGB1 mediated autophagy and apoptosis in human nucleus pulposus cells; chloroquine amplified apopto
HMGB1 mediated autophagy and apoptosis in human nucleus pulposus cells; chloroquine amplified apoptosis by inhibiting autophagyAbstractInvestigate the cellular response of human nucleus pulposus (H...
Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cance
Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cancerAbstractCurcumin has attracted attention for its nontoxic chemopreventive effects; however, the ...
Identification and localization of telocyte-like cells in human umbilical cord stromaAbstractHuman umbilical cord (hUC) connective tissue, known as Wharton’s jelly, contains multipotent stromal cel...
The methyl-CpG-binding protein 2 inhibits cGAS-associated signalingAbstractThe detection of cytosolic dsDNA by the cyclic GMP-AMP synthase (cGAS) is tightly regulated to avoid pathological inflamma...
Age affects the immune system more than a moderate surgical trauma and anesthesiaAbstractThe effectiveness of the immune system decreases with increasing age. This process is known as immunosenesce...
Exploring the molecular mechanism of apigenin in treating bronchiectasis based on network pharmacolo
Exploring the molecular mechanism of apigenin in treating bronchiectasis based on network pharmacology and molecular dockingAbstractBronchiectasis is a complex, heterogeneous inflammatory chronic r...
Lysosomal and mTORC1 signaling dysregulation underpin the pathology of spastic paraplegia type 80AbstractEndosomal sorting complex required for transport (ESCRT) is the major membrane remodeling co...
Pre-rRNAs control mitosis by maintaining chromosomal segregation through protecting SMC2 from AURKA-
Pre-rRNAs control mitosis by maintaining chromosomal segregation through protecting SMC2 from AURKA-mediated phosphorylationAbstractIn interphase, 47S pre-rRNA is transcribed by RNA polymerase I (P...
The composition and structure of the outer kinetochore KMN complex is conserved across kingdomsAbstractIn eukaryotes, chromosome segregation relies on attachment to the spindle, ensured by the kine...
The use of Janus kinase inhibitors to treat noninfectious uveitisAbstractObjectiveTo present a case series of eight patients with noninfectious chronic uveitis treated at a single institution with ...
Pathogenic drivers of lupus myocarditis and potential therapeutic targetsAbstractSystemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organs simultaneously, comp...
Circulating endotoxin is correlated with fatty acid binding protein 2 and leukocyte nuclear factor-κ
Circulating endotoxin is correlated with fatty acid binding protein 2 and leukocyte nuclear factor-κB activation in menopausal womenAbstractCirculating endotoxin is mainly derived from gut microbio...
Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive o
Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive ovarian cancer: the randomized phase 2 SOLACE2 trialAbstractSOLACE2 (ACTRN12618000686202) investig...
Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammat
Safety and immunogenicity of PPV-06, an active anti-IL-6 immunotherapy targeting low-grade inflammation against knee osteoarthritis: a randomized, double-blind, placebo-controlled, clinical phase 1...
Aerosol and intranasal delivery of monoclonal antibodies to prevent transmission in pig influenza in
Aerosol and intranasal delivery of monoclonal antibodies to prevent transmission in pig influenza infection modelsAbstractThere is an urgent need for robust animal models to assess novel therapies ...
Unravelling the cellular sources and location of IL-17A production during a Giardia infectionAbstractIL-17A plays a crucial role in the immune defense against Giardia infection, yet its cellular so...
Novel small molecule inhibitor of GPR68 attenuates endothelial dysfunction and lung injury caused by
Novel small molecule inhibitor of GPR68 attenuates endothelial dysfunction and lung injury caused by bacterial lipopolysaccharideAbstractThe treatment of acute respiratory distress syndrome (ARDS) ...
The tumor microenvironment enhances the expression of cssDNA by modulating cell cycle signaling path
The tumor microenvironment enhances the expression of cssDNA by modulating cell cycle signaling pathways via SKP2AbstractCircular single-stranded DNA (cssDNA), an emerging nucleic acid vector, exhi...
Targeting FSP1 triggers ferroptosis in lung cancerAbstractEmerging evidence indicates that cancer cells are susceptible to ferroptosis, a form of cell death that is triggered by uncontrolled lipid ...
Spatial single-cell atlas reveals regional variations in healthy and diseased human lungAbstractIntegration of scRNA-seq data from millions of cells revealed a high diversity of cell types in the h...
Thyme oil mitigates cadmium-induced oxidative and genotoxic stress in Vicia faba root meristem cells
Thyme oil mitigates cadmium-induced oxidative and genotoxic stress in Vicia faba root meristem cells under in vitro conditionsAbstractCadmium is considered one of the most toxic and dangerous envir...
Secretome translation shaped by lysosomes and lunapark-marked ER junctionsAbstractThe endoplasmic reticulum (ER) is a highly interconnected membrane network that serves as a central site for protei...
Bone marrow mesenchymal stem cell exosome-derived miR-223 regulated cellular pyroptosis of macrophag
Bone marrow mesenchymal stem cell exosome-derived miR-223 regulated cellular pyroptosis of macrophage in osteomyelitis through regulating LACC1AbstractOsteomyelitis (OM) is a severe bone infection ...
Human fingertip regeneration follows clinical phases with distinct proteomic signaturesAbstractDistal injuries in human fingertips can regenerate almost fully, yet the process of human fingertip re...
Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative bre
Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative breast cancerAbstractGangliosides are acidic glycosphingolipids involved in cell-adhesion, signal-tr...
Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and linea
Transcription factor ZNF263 primes human embryonic stem cells for pluripotency dissolution and lineage commitmentAbstractConventional human embryonic stem cells (hESCs) are capable of self-renewal ...
Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, op
Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, open-label, single-arm, safety trialAbstractLiver transplantation remains constrained by the scarci...
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